About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Autoimmune Kidney Disease can be Detected by Simple Blood Tests

by Kathy Jones on September 9, 2012 at 9:01 PM
Font : A-A+

 Autoimmune Kidney Disease can be Detected by Simple Blood Tests

A study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN)says that simple blood tests could help physicians decide which patients with a particular autoimmune kidney disease can forgo potentially toxic medications and which need to be treated.

Idiopathic membranous nephropathy is an autoimmune kidney disease that leads to kidney failure in at least half of patients if left untreated. Immunosuppressive therapy is effective, but toxic. "It is unclear who should be treated, when treatment should be started, and how long treatment should be continued. We need better tools to aid decision-making," said Julia Hofstra, MD, PhD (Radboud University Nijmegen Medical Center, in The Netherlands).

Advertisement

Researchers have recently identified antibodies-called antiPLA2R autoantibodies-that form and damage the kidneys when the disease develops. Clinicians do not have a standard technique for measuring these autoantibodies nor do they know whether autoantibody levels provide any information about the severity of patients'' disease.

Hofstra, in collaboration with Hanna Debiec, PhD (Institut National de la Santé et de la Recherche Médicale, in France), Paul Brenchley, PhD (University of Manchester, in the United Kingdom), and others compared two different blood tests (called IIFT and ELISA) to measure antiPLA2R autoantibodies in 117 patients with idiopathic membranous nephropathy.
Advertisement

Among the major findings:
- 74% of patients tested positive for antiPLA2R antibodies by IIFT and 72% tested positive by ELISA.
- Concordance between both tests was excellent, with 94% agreement.
- Antibody levels significantly correlated with the severity of patients'' disease.
- Spontaneous remissions occurred much less frequently among patients with high antibody levels (38% versus 4% in the lowest and highest groups, respectively).

The findings reveal high agreement between IIFT and ELISA measurements of antiPLA2R antibody levels and highlight the important role of these antibodies in idiopathic membranous nephropathy, given the relationships between antiPLA2R levels, disease severity, and remission rates.

"The data provide hope that in the near future, antiPLA2R antibodies can be detected with a simple assay and measuring the antibody levels may improve optimal treatment in patients with idiopathic membranous nephropathy," said Dr. Hofstra.

Study co-authors include Colin Short, MD, FRCP, Timotheé Pellé, Robert Kleta, MD, PhD, Peter Mathieson, PhD, FRCP, Pierre Ronco, MD, PhD, and Jack Wetzels, MD, PhD.

Disclosures: The authors reported no financial disclosures.

The article, entitled "Antiphospholipase A2 Receptor Antibody Titer and Subclass in Idiopathic Membranous Nephropathy," will appear online at http://jasn.asnjournals.org/ on September 6, 2012, doi: 10.1681/ASN.2012030242.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with more than 13,500 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.



Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Kidney Health Stones in Urinary Tract Myasthenia Gravis Vitiligo 

Most Popular on Medindia

Sanatogen Blood Donation - Recipients Vent Forte (Theophylline) Blood - Sugar Chart Post-Nasal Drip Blood Pressure Calculator Find a Doctor Drug Side Effects Calculator A-Z Drug Brands in India Color Blindness Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT ONLINE WITH A DOCTOR

×

Autoimmune Kidney Disease can be Detected by Simple Blood Tests Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests