The risk of developing seven autoimmune diseases is inherited, and some of these diseases are closely related than others, said researchers. These results will be presented Sunday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.
"These results contribute to our understanding of what causes autoimmunity and how autoimmune diseases are related," said Jakob Skov, M.D., the study's lead investigator and a Ph.D. student at the Karolinska Institute in Stockholm, Sweden. "We examined the risk of acquiring not only one specific disease, but any one in a cluster of conditions. The findings may be helpful in patient education and autoimmune risk counselling."
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‘Addison's disease; celiac disease; and type 1 diabetes, are strongly influenced by genes with heritability greater than 85 percent, while environmental factors contribute to disease for Hashimoto's hypothyroidism; the skin disease vitiligo; Graves' disease, an overactive thyroid; and atrophic gastritis, a chronic inflammation of the stomach.’
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Autoimmune diseases tend to run in families. The basis of twin studies is to examine concordance rates--the likelihood of both twins in a pair having the same disease. Higher concordance rates in identical than in non-identical twins point to genetic influence. This information is typically used to calculate heritability--a measure of how much of the variation in disease risk is due to genetic factors. Skov and his co-workers also looked at the likelihood of both twins in a pair having different autoimmune diseases--which they named "pseudoconcordance" - and compared these rates to measure autoimmune clustering.
By using data on 116,320 twins from the Swedish Twin Registry, which is managed by the Karolinska Institute, they found that Addison's disease, a type of adrenal insufficiency; celiac disease, or gluten intolerance; and type 1 diabetes, are strongly influenced by genes with heritability greater than 85 percent, while environmental factors contribute to disease for Hashimoto's hypothyroidism, a form of underactive thyroid; the skin disease vitiligo; Graves' disease, an overactive thyroid; and atrophic gastritis, a chronic inflammation of the stomach.
![Quiz on Celiac Disease]( "Quiz on Celiac Disease")
Reactions to specific types of food are quite common. Many children suffer from milk and egg allergy. Celiac disease is one such condition, caused due to intake of specific foods in sensitive individuals. Test your knowledge on celiac disease by taking this quiz.
Autoimmune clustering was high in Addison's disease and vitiligo, the researchers found, but low in celiac disease.
"Our results indicate that Addison's disease and vitiligo often overlap with other disorders, whereas celiac disease more rarely associates with the other diseases," Skov said.
Source: Eurekalert
Quiz on Celiac Disease
Reactions to specific types of food are quite common. Many children suffer from milk and egg allergy. Celiac disease is one such condition, caused due to intake of specific foods in sensitive individuals. Test your knowledge on celiac disease by taking this quiz.
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Autoimmune clustering was high in Addison's disease and vitiligo, the researchers found, but low in celiac disease.
"Our results indicate that Addison's disease and vitiligo often overlap with other disorders, whereas celiac disease more rarely associates with the other diseases," Skov said.
Source: Eurekalert
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 Testosterone Deficiency – A Risk for Autoimmune DiseasesMore women than men develop autoimmune diseases and testosterone may explain this gender differences in the occurrence of rheumatism and other autoimmune diseases. Testosterone deficiency in men is also associated with increased risk for autoimmunity. | Advertisement
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