One gene in particular, known as GTF2I, showed a high likelihood of being involved in the development of lupus.
Systemic Lupus Erythematosus (SLE) - Causes, Symptoms, Diagnosis and Treatment
Systemic Lupus Erythematosus (SLE) is an autoimmune disease that affects multiple organs like the joints, skin, kidney, heart, lungs, blood vessels and brain.
Systemic Lupus Erythematosus (SLE) is an autoimmune disease that affects multiple organs like the joints, skin, kidney, heart, lungs, blood vessels and brain.
‘Indian-origin scientist has successfully identified 10 new genes associated with lupus - a debilitating chronic autoimmune disease.’
Researchers identified the condition in nearly 4,500 volunteers while the rest were taken as controls. They identified ten distinct DNA sequence variants linked to lupus. "We know lupus has a strong genetic basis, but in order to better treat the disease we have to identify those genes," said Swapan Nath from Oklahoma Medical Research Foundation (OMRF) in US, who led the study.
One gene in particular, known as GTF2I, showed a high likelihood of being involved in the development of lupus, researchers said.
Current Treatment Options for Lupus Nephritis
Cyclophosphamide or MMF with a corticosteroid is the first treatment choice for lupus nephritis. On the other hand, azathioprine or MMF combined with a corticosteroid is useful as maintenance therapy.
Cyclophosphamide or MMF with a corticosteroid is the first treatment choice for lupus nephritis. On the other hand, azathioprine or MMF combined with a corticosteroid is useful as maintenance therapy.
"These findings mark a significant advance in our knowledge base for lupus genes. For every gene we identify, it brings us closer to uncovering the trigger for this puzzling disease,” said Judith James from OMRF.
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Scientists Unmask Mitochondrial Troublemakers in Lupus
Researchers are discovering more about how these chemicals and other mitochondrial materials provoke the body's self-attack in systemic lupus erythematosus.
Researchers are discovering more about how these chemicals and other mitochondrial materials provoke the body's self-attack in systemic lupus erythematosus.
Inhibiting an Enzyme can Help Fight Autoimmune Diseases Such as SLE
An enzyme, called cGAS, sounds an alarm for the body's innate immune system. Activating this enzyme causes AGS and SLE, while inhibiting it rescues them.
An enzyme, called cGAS, sounds an alarm for the body's innate immune system. Activating this enzyme causes AGS and SLE, while inhibiting it rescues them.
