Medindia
Advertisement

Autism Genes Activated During Fetal Brain Development

by Shirley Johanna on February 19, 2015 at 4:40 PM

 Autism Genes Activated During Fetal Brain Development
Autism genes are activated during fetal brain development, revealed a new research. Scientists at the University of California, San Diego School of Medicine have found that mutations that cause autism in children are connected to a pathway that regulates brain development.

Lead researcher Lilia Iakoucheva, PhD said that the surprising thing they immediately observed while studying a set of well-known autism mutations called copy number variants or CNVs, was that different CNVs seemed to be turned on in different developmental period.
Advertisement

Specifically, the scientists noted that one CNV located in a region of the genome known as 16p11.2, contained genes active during the late mid-fetal period. Ultimately, they identified a network of genes that showed a similar pattern of activation including KCTD13 within 16p11.2 and CUL3, a gene from a different chromosome that is also mutated in children with autism.

Iakoucheva said that they realized that the proteins encoded by the genes, form a complex that regulates the levels of a third protein, RhoA. Rho proteins play critical roles in neuronal migration and brain morphogenesis at early stages of brain development.
Advertisement

Interestingly, the RhoA pathway has recently been implicated in a rare form of autism called Timothy syndrome, which is caused by the mutation in a completely different gene.

Iakoucheva and colleagues are planning to test RhoA pathway inhibitors using a stem cell model of autism.

The research is published in Neuron.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Lower Respiratory Tract Infections Linked to Obstructive Sleep Apnea in Children
Type 2 Diabetes can be Controlled by Unripen Green Jackfruit Flour
Covid Pandemic: How Parents can Help Kids Deal with Back-to-School Anxiety
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Autism Parkinsons Disease Parkinsons Disease Surgical Treatment Brain Brain Facts Ataxia Rett Syndrome Weaver Syndrome Nutrition and Cognitive Development in Young Children Acquired Epileptiform Aphasia 

Recommended Reading
Autism
Autism is a neurodevelopmental disorder typically characterized by impaired social and ......
Non-Syndromic Autism: New Genetic Links Revealed Using Multiple Models
Autism is a pervasive developmental disorder. In medical terms, it is called as a ......
Autism Spectrum Disorder Costs Almost $2.4 Million Per Patient
A study recently researched the economic impact of autism spectrum disorders....
In Children With Autism, Early Brain Responses to Words Predict Developmental Outcomes
According to a new study, the pattern of brain responses to words in 2-year-old children with ......
Acquired Epileptiform Aphasia
Acquired Epileptiform Aphasia or Landau –Kleffner Syndrome (LKS) is a rare childhood disorder in whi...
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Nutrition and Cognitive Development in Young Children
Nutrition plays an important role in cognitive development of children. Various mental assessment sc...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Rett Syndrome
Rett Syndrome is a neurological disorder that affects development. It mostly affects the girl ......
Weaver Syndrome
Weaver syndrome is a genetic disorder in which children show accelerated bone growth, advanced bone ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use