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Australian Researchers Develop Solution To Treat Surgical Tools

by Gopalan on October 15, 2009 at 12:44 PM
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 Australian Researchers Develop Solution To Treat Surgical Tools

Australian researchers have created a solution to treat surgical tools against possible transmission of Creutzfeldt-Jakob disease (CJD).

Creutzfeldt-Jakob disease (CJD) is caused when protein like particles called prions attack the brain leading to mental deterioration and ultimately death. It can be contracted via contaminated surgical equipment. Currently less than one per cent of tools are treated against prions.

Novapharm Research (Australia) Pty Ltd, in collaboration with the University of Melbourne, has developed solutions which break up and deactivate the rogue protein molecules of CJD.


The outcome is cost effective, will enable all medical instruments to be treated against prions, will not disrupt current surgical procedures and is easily incorporated into current cleaning protocols.

The importance of this is that CJD and other prion diseases have no known cure and can have a lengthy symptom-free incubation period of decades.

The human prion is resistant to both heat and chemicals and is reported to be up to a hundred thousand times more difficult to deactivate than the animal form of infective agent which causes well known diseases in cattle, such as mad cow disease, and scrapie in sheep.

Any error in identifying a CJD-carrier can be fatal and costly - many hospitals around the world have been forced to destroy millions of dollars worth of instruments when patients were diagnosed with CJD some time after undergoing routine eye and neurosurgical procedures.

A further factor limiting decontamination from prions is that existing cleaning protocols are damaging to medical instruments such as flexible endoscopes and some instruments used in neurosurgical, dental and opthalmological procedures.

It is estimated that currently less than one per cent of medical instruments are treated against prions, with hospital procedures relying on staff to identify potential carriers.

The treatment process was optimised and performed by a research team in the Department of Pathology at the University of Melbourne led by Dr Victoria Lawson. The University of Melbourne is Australia's leading prion disease research centre.

Novapharm's prion deactivating solutions have been approved by the Australian Therapeutic Goods Administration and have full CE certification for distribution in the European Union.

According to Mr Steve Kritzler, a director of Novapharm, there should be widespread interest from hospitals around the world in a solution that can deactivate prions on all medical instruments, including flexible endoscopes.

"This solution fills a gaping hole in current infection control practices which basically rely on hospital staff identifying 'high risk patients' of these diseases which don't have obvious symptoms," Mr Kritzler said.

"The new instrument reprocessing solutions developed by Novapharm can also be cost effective for hospitals, GPs, dentists, and vets since they will work with existing cleaning equipment and are highly effective as a general pre-cleaner compatible with any surgical or medical instruments.

"We expect hospitals in the UK to be particularly interested in our solution since it has been the location for a number of CJD incidents in the past," Mr Kritzler added.

The commercial formulations will be sold in Australia under trade names Asepti RAPIDZYME Pr and Asepti AUTOZYME Pr.

The solutions are derived from naturally occurring enzymes which have been specifically formulated to attack the structure of prions while maintaining characteristics which allow use as a general pre-cleaner of surgical and medical instruments.

Source: Medindia

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