Football players with sickle cell trait (SCT) are at a higher risk of collapsing during periods of extreme physical exertion, reports a new study. The findings of the study are published in Southern Medical Journal.
A recent study led by researchers from the University of South Florida identifies a genetic variation known to affect sickle cell disease symptomology. This finding may explain why some collegiate football players with sickle cell trait (SCT) experience adverse clinical outcomes during periods of extreme physical exertion and others do not.
Sickle Cell Anemia
Sickle cell anemia (SCA) is a genetic blood disorder caused by abnormal inherited hemoglobin. Sickle cell anemia is the most common form of sickle cell disease.
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‘Athletes (particularly football players) with sickle cell trait are at a higher risk of developing adverse clinical outcomes during periods of extreme physical exertion.’
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This double-blind study is the first of its kind to test the hypothesis that genetic markers associated with the production of fetal hemoglobin are associated with symptom variation in a sample of collegiate football players. Results also showed that there are significant associations between symptomology and player body mass index (BMI), and weight and symptomology.
The study research team, which includes Arizona State University, genotyped collegiate athletes with SCT for single nucleotide polymorphisms (SNPs) previously shown to affect levels of fetal hemoglobin and asked the athletes to complete a survey about the presence of symptoms associated with exercise collapse associated with sickle cell trait, and to compare themselves with their peers without SCT.
![Positive Gene Editing for Sickle Cell Disease and Beta Thalassemia]( "Positive Gene Editing for Sickle Cell Disease and Beta Thalassemia")
New approach to gene editing for major blood disorders such as sickle cell disease and beta-thalassemia has been optimized. CRISPR-Cas9 gene editing can edit out diseased genes in blood disorders.
"We know of at least 22 sickle cell trait athletes that have died due to complications associated with their 'benign' condition. These individuals were young and in excellent health," said Lorena Madrigal, Ph.D., Professor of Anthropology at the University of South Florida.
"The results of this study show significant associations between SNPs and symptoms, and between one SNP and greater body weight and body mass index. It is our hope that this information will provide parents, coaching and medical staff a better understanding of the more complex interactions among the sickle cell gene and the modifiers that affect it."
Clinicians have known that sickle cell disease patients differ in their clinical symptomology. They also know that better outcomes are due to higher levels of fetal hemoglobin. These study results demonstrate the same to be true for sickle cell trait individuals, particularly for football players. Additional testing on a larger sample of athletes is planned for the future.
Source: Eurekalert
Positive Gene Editing for Sickle Cell Disease and Beta Thalassemia
New approach to gene editing for major blood disorders such as sickle cell disease and beta-thalassemia has been optimized. CRISPR-Cas9 gene editing can edit out diseased genes in blood disorders.
Advertisement
"We know of at least 22 sickle cell trait athletes that have died due to complications associated with their 'benign' condition. These individuals were young and in excellent health," said Lorena Madrigal, Ph.D., Professor of Anthropology at the University of South Florida.
"The results of this study show significant associations between SNPs and symptoms, and between one SNP and greater body weight and body mass index. It is our hope that this information will provide parents, coaching and medical staff a better understanding of the more complex interactions among the sickle cell gene and the modifiers that affect it."
Clinicians have known that sickle cell disease patients differ in their clinical symptomology. They also know that better outcomes are due to higher levels of fetal hemoglobin. These study results demonstrate the same to be true for sickle cell trait individuals, particularly for football players. Additional testing on a larger sample of athletes is planned for the future.
Source: Eurekalert
How Does Acute Pain Crisis in Sickle Cell Disease Arise?
Steps leading to a sickle-cell disease complication that causes acute pain have been explained by MIT researchers.
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 Impact of Opioids on Pain and Survival in Sickle Cell DiseaseSickle cell disease produces severe pain which is treated with painkillers like opioids. Effects of opioids with respect to survival and pain were studied. | Advertisement
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