A component of aspirin can bind to GAPDH and block cell death associated with these neurodegenerative diseases.

‘A component of aspirin can bind to an enzyme called GAPDH, which is believed to play a major role in neurodegenerative diseases like Alzheimer's, Parkinson's and Huntington's disease.’

Salicylic acid is the primary breakdown product of aspirin. Klessig explained, "A better understanding of how salicylic acid and its derivatives regulate the activities of the key protein can lead to the development of new and better salicylic acid-based treatments of a wide variety of devastating diseases."





Klessig further added, "A better understanding of how salicylic acid and its derivatives regulate the activities of GAPDH and HMGB1, coupled with the discovery of much more potent synthetic and natural derivatives of salicylic acid, provide great promise for the development of new and better salicylic acid-based treatments of a wide variety of prevalent, devastating diseases."
The study appeared in PLOS ONE.
Source-IANS