Through an artificial placenta that mimics the womb, researchers at the University of Michigan are working to improve survival rates in the tiniest, most premature babies in a groundbreaking way.
The technology hasn't reached a clinical trial, but researchers from U-M's C.S. Mott Children's Hospital and Extracorporeal Circulation Research Laboratory are making dramatic progress. An extracorporeal artificial placenta at the institution has kept five extremely premature lambs alive for a week. The lambs were transferred to the artificial placenta which utilizes extracorporeal membrane oxygenation (ECMO) without ever taking their first breath.
Parents of Premature Babies are More Worried About Their Child's Lives
Parents of very premature babies are more worried about their grown-up child's lives than parents whose babies are born in full term, says a study.
Advertisement
‘An extracorporeal artificial placenta may help survive extremely premature babies with the greatest risks of disability or death.’
Tweet it Now
The ultimate goal of nearly a decade of sustained work: for an artificial placenta to help extremely premature babies with the greatest risks of disability or death continue critical organ development outside of their mother's womb.
A complete paradigm shift
Despite significant advances in the treatment of prematurity, the risk of death and long-term disability remains high for extremely premature infants born before 24 weeks - these babies' tiny bodies simply are not prepared for life outside the womb.
![Imbalance of Gut Microbes Linked to Deadly Intestinal Disease in Premature Babies]( "Imbalance of Gut Microbes Linked to Deadly Intestinal Disease in Premature Babies")
An imbalance of certain gut microbes appears to be the underlying cause of a frequently fatal intestinal illness in premature babies.
"One of the gravest risks for extremely premature babies is undeveloped lungs that are too fragile to handle even the gentlest ventilation techniques," says George Mychaliska, M.D., the principle investigator and director of the U-M's Fetal Diagnosis and Treatment Center. "If a baby's lungs are severely immature, they cannot provide the brain, heart and other organs the oxygen they need to survive."
Mychaliska, who has been referred to as Michigan's "fetus fixer" for his renowned fetal intervention work, has been leading research to improve outcomes for premature infants.
"We thought why don't we solve the problem of prematurity by recreating the intrauterine environment?" he says. "Maybe we should treat this tiny baby like a fetus. Maybe we should treat these babies as if they are still in the womb. This is a complete paradigm shift. Our research is still in a very preliminary stage, but we've passed a significant milestone that gives us promise of revolutionizing the treatment of prematurity.
"Although many of our current therapies are life-saving, they are not designed for premature babies and are often ineffective or contribute to complications," he adds.
How it works
The innovative artificial placenta simulates the intrauterine environment and provides gas exchange without mechanical ventilation. By recapitulating normal fetal physiology to recreate the intrauterine environment, the artificial placenta holds the promise of normal growth and development outside the womb for extremely premature infants until they are ready for postnatal life. The success of keeping lambs alive through this technique was a crucial milestone in securing a $2.7 million R01 NIH grant helping accelerate this research.
The way forward
Over the next five years, researchers expect to demonstrate that an artificial placenta can be used to simulate the intrauterine environment and support a fetal lamb from extreme prematurity to normal newborn physiology. The next step would be to determine if the milestones would justify preliminary clinical trials in extremely premature babies.
Source: Newswise
Despite significant advances in the treatment of prematurity, the risk of death and long-term disability remains high for extremely premature infants born before 24 weeks - these babies' tiny bodies simply are not prepared for life outside the womb.
Imbalance of Gut Microbes Linked to Deadly Intestinal Disease in Premature Babies
An imbalance of certain gut microbes appears to be the underlying cause of a frequently fatal intestinal illness in premature babies.
Advertisement
"One of the gravest risks for extremely premature babies is undeveloped lungs that are too fragile to handle even the gentlest ventilation techniques," says George Mychaliska, M.D., the principle investigator and director of the U-M's Fetal Diagnosis and Treatment Center. "If a baby's lungs are severely immature, they cannot provide the brain, heart and other organs the oxygen they need to survive."
Mychaliska, who has been referred to as Michigan's "fetus fixer" for his renowned fetal intervention work, has been leading research to improve outcomes for premature infants.
"We thought why don't we solve the problem of prematurity by recreating the intrauterine environment?" he says. "Maybe we should treat this tiny baby like a fetus. Maybe we should treat these babies as if they are still in the womb. This is a complete paradigm shift. Our research is still in a very preliminary stage, but we've passed a significant milestone that gives us promise of revolutionizing the treatment of prematurity.
"Although many of our current therapies are life-saving, they are not designed for premature babies and are often ineffective or contribute to complications," he adds.
How it works
The innovative artificial placenta simulates the intrauterine environment and provides gas exchange without mechanical ventilation. By recapitulating normal fetal physiology to recreate the intrauterine environment, the artificial placenta holds the promise of normal growth and development outside the womb for extremely premature infants until they are ready for postnatal life. The success of keeping lambs alive through this technique was a crucial milestone in securing a $2.7 million R01 NIH grant helping accelerate this research.
The way forward
Over the next five years, researchers expect to demonstrate that an artificial placenta can be used to simulate the intrauterine environment and support a fetal lamb from extreme prematurity to normal newborn physiology. The next step would be to determine if the milestones would justify preliminary clinical trials in extremely premature babies.
Source: Newswise
Premature Babies at High Risk of Developing Autism Later
Babies born more than 13 weeks prematurely run a serious risk of brain damage, autism and learning difficulties as they are exposed to numerous stress factors.
Advertisement
 Simple Raisin Test Can Predict Learning Disabilities in Premature BabiesMost of the premature babies would have a tendency to grab the raisin immediately. But if they wait for a minute then their learning ability will be greater | Advertisement
|
Advertisement
Recommended Reading
Latest Child Health News
To tackle the rising cases of autism among kids, steady screening programs may make a difference in autism diagnosis and treatment.
Children with autism tend to receive vision screening less often, despite having a high risk for eye problems.
Interrupting independent play time can affect the mental health of children. Engaging in independent activities can also reduce anxiety and depression in kids.
Obesity risk increases in children with autism spectrum disorder (ASD), raising the probability of developing cardiometabolic disorders.
125 pediatric influenza flu deaths have been reported so far this season in the United States, according to the CDC.