About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Arthritis Drugs Could also Be Useful in Treating Heart Conditions

by Gopalan on July 19, 2008 at 11:14 AM
Font : A-A+

 Arthritis Drugs Could also Be Useful in Treating Heart Conditions

Professor Marc Feldmann says drugs now used to treat rheumatoid arthritis could also hold the key to many more medical conditions, including atherosclerosis - a leading cause of heart disease.

The drugs he and his colleagues developed for arthritis had already proved successful against other autoimmune diseases, Professor Marc Feldmann told the 2008 Congress of European Pharmacological Societies (EPHAR), held at Manchester.

Advertisement

The immune system is the body's front line of defence against disease-causing invaders such as bacteria, viruses and parasites.

However, sometimes this formidable defender can turn against us - mistakenly attacking and damaging the body's own tissues. This case of mistaken identity is the cause of common autoimmune diseases such as type one diabetes, rheumatoid arthritis and lupus.
Advertisement

Feldmann said, "In autoimmune diseases, such as arthritis, we discovered that cytokines (protein messaging molecules) are over-produced causing the immune system to fight itself, resulting in inflammation and tissue destruction."


"We further found that by blocking just one cytokine - Tumor Necrosis Factor (TNF) alpha - we were able to block all the cytokines involved in the inflammation, with remarkable clinical results."

His team's research led to the development of three anti-TNF alpha drugs - infliximab, etanercept and adalimumab - which have had a dramatic effect on the symptoms of rheumatoid arthritis patients, protecting the joints from further deterioration in the vast majority of cases.

Blocking TNF alpha has had further success in treating several more chronic inflammatory conditions, including Crohn's disease, psoriasis, psoriatic arthritis, ankylosing spondylitis and ulcerative colitis.

But Professor Feldmann, Head of the Kennedy Institute of Rheumatology, believes similar drugs have the potential to treat many other medical conditions, particularly on arthosclerosis.

His work with his colleague Dr Claudia Monaco has resulted in the emergence of a new branch of medicine - anti-cytokine therapy - and research elsewhere has showed promise in yet more conditions, including the potentially fatal acute alcoholic hepatitis.

Professor Feldmann had said on the eve of the conference: "During the conference I will be discussing the potential therapeutic targets in tissue affected by atherosclerosis, which is caused by a chronic inflammatory response in the walls of the arteries, in large part, caused by an excessive immune response to cholesterol.

"I will also discuss whether it is possible - even likely - that cytokines play a critical role in all diseases involving multiple biological processes, thus providing therapeutic targets for all unmet medical needs."






Source: Eurekalert
GPL
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Osteoarthritis Oligoarthritis Spondylolisthesis Signature Drug Toxicity Knee Replacement Heart Healthy Heart Reactive Arthritis Statins 
Recommended Reading
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Knee Replacement
Make sprinting a possibility! Relieve chronic arthritic pain by having a knee replacement done at ...
Oligoarthritis
Most parents when told that their child has arthritis find it hard to believe it, as arthritis is re...
Osteoarthritis
Osteoarthritis is one of the commonest joint disorder and occurs as we age due to wear and tear of a...
Reactive Arthritis
Reactive arthritis is an autoimmune condition. Ankylosing spondylitis, psoriatic arthritis are disor...
Spondylolisthesis
Spondylolisthesis is a condition of the lower spine in which one of the bones of the vertebral colum...
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use