Antiviral Drug Telbivudine Prevents Transmission of Hepatitis B Virus During Pregnancy

by Dr. Trupti Shirole on June 4, 2015 at 7:23 AM
Font : A-A+

Antiviral Drug Telbivudine Prevents Transmission of Hepatitis B Virus During Pregnancy

Hepatitis B virus is a leading cause of liver disease. It has infected nearly two billion people worldwide. A new study has found that an antiviral drug telbivudine prevents perinatal transmission of hepatitis B virus (HBV).

Study author Yuming Wang from Institute for Infectious Diseases, Southwest Hospital, Chongqing, China, said, "If we are to decrease the global burden of hepatitis B, we need to start by addressing mother-to-infant transmission, which is the primary pathway of HBV infection. We found that telbivudine not only eliminated vertical transmission of HBV from pregnant women to theirs infants, but that it is also safe and well tolerated by women and infants."


Researchers studied 450 HBV-positive pregnant women with high viral load, or significant HBV in the blood, during the second or third trimester of pregnancy. Out of them, 279 women received telbivudine (600 mg daily) during weeks 24 through 32 of gestation, and 171 women who were unwilling to take antiviral drugs participated as controls.

At six months after birth, none of the infants whose mothers were given telbivudine tested positive for HBV, compared to 14.7% of infants in the control group. Almost half of the mothers who received telbivudine had no HBV detectable in their system, while those not on the antiviral medication all tested positive for HBV. A significantly higher proportion of women given telbivudine had undetectable levels of HBV DNA in cord blood (99.1%) than controls (61.5%).

Wang said, "No severe adverse events or complications were observed in women or infants. The long-term influence of using telbivudine, especially when compared to the other recommended oral antiviral drug, tenofovir, remains to be explored."

The study is published in Clinical Gastroenterology and Hepatology.

Source: Medindia

News A-Z
News Category
What's New on Medindia
Sedentary Behavior Precipitates Night-Time Hot Flashes
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chicken Pox Drug Toxicity Trimester of pregnancy Pregnancy and Exercise Hepatitis A Hepatitis B Home Pregnancy Test Pregnancy Psychological Changes In Pregnancy Shigellosis 

Recommended Reading
HBV Screening
Tests used for screening hepatitis B are estimation of hepatitis B surface antigen (HBsAg), ......
Entecavir, An Effective Antiviral Drug, may Help Treat Hepatitis B Virus Infection
Hepatitis B drug, entecavir, could be mass produced for only $36 per person per year. Combining ......
Songbird Fossils Reveal That Hepatitis B Virus may be Over 19-mn-year-old
Biologists at The University of Texas at Arlington were able to locate fragments of the modern ......
Clue To Hepatitis B Virus Genetic Code Lies With 16th-Century Korean Mummy
A mummified Korean child with fairly preserved organs enabled to perform a genetic analysis on a ......
Chicken Pox
Chicken pox is an acute and highly contagious viral infection caused by the varicella zoster virus....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Hepatitis A
Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. H...
Hepatitis B
Hepatitis B is inflammation of the liver due to infection with the hepatitis B virus....
Home Pregnancy Test
A home pregnancy test is a test done to find out if one is pregnant or not in the relative comforts ...
Detailed look at Early pregnancy Symptoms and easy health solutions during 1st, 2nd and 3rd trimeste...
Psychological Changes In Pregnancy
Pregnancy is an experience of growth, change, enrichment and challenge. During the 40 weeks of pregn...
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...
Trimester of pregnancy
Encyclopedia section of medindia explains in brief about confirmation of pregnancy in first ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use