About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Antioxidants Found in Legumes, Bran may Protect DNA Against UV Radiation

by VR Sreeraman on November 5, 2007 at 7:00 PM
Font : A-A+

Antioxidants Found in Legumes, Bran may Protect DNA Against UV Radiation

Researchers from the University of Maryland have found that two common dietary molecules found in legumes and bran could protect DNA from the harmful effects of radiation. The molecules - Inositol and inositol hexaphosphate (IP6) - were tested in human skin cells and a skin cancer-prone mouse that were exposed to ultraviolet B (UVB) radiation, the damaging radiation found in sunlight.

Researchers found that the two molecules decreased the severity of side effects from radiation therapy, saving healthy cells while simultaneously increasing the potency of the treatment against cancer cells. "Both of these potent antioxidants have been shown to have broad-spectrum anti-tumor capabilities, and now our studies confirm the degree to which these molecules protect against the DNA-damaging effects of ionizing radiation," said lead researcher Abulkalam M. Shamsuddin, M.D., professor of pathology at the University of Maryland School of Medicine.

Advertisement

"Radiation damage is radiation damage, regardless of the source, so there could also be a protective role for IP6 in any form of radiation exposure, whether it is from a therapeutic dose or from solar, cosmic or nuclear sources." Inositol and IP6 are related to B vitamins, they are however not considered essential dietary nutrients. They are present in abundance within the hulls of seeds and grains.

They have already been found to have definitive protective effects against colorectal cancer. With funding from IP-6 Research, Inc., a company formed by Shamsuddin, the researchers began a study to determine how human skin cells responded to UVB radiation when dosed with IP6.
Advertisement

Normally, cells permanently damaged by radiation undergo a genetically programmed process of cell suicide, called apoptosis. However, UVB-irradiated human keratinocytes, when treated with IP6, were more likely to survive. Untreated skin cells were more likely to undergo apoptosis, indicating that the DNA in those cells was damaged irreparably and fatally.

"IP6 certainly has some interactivity with DNA, but how exactly it works to repair DNA is still something of a mystery. There are reports that IP6 binds with DNA repair molecule Ku to bring about the repair process," Shamsuddin said. "More importantly, we still don't know how IP6 can appear to help healthy cells live while also enhancing the ability of radiation to kill cancer cells."

On the study conducted on a mouse model, the researchers gave rodents engineered to be prone to skin cancer drinking water containing a two-percent solution of IP6. These rats were found to be less likely to develop tumours. Similarly, the team also noted that mice treated with a topical cream containing four percent IP6 plus one percent inositol were also less likely to develop tumours.

The team now says that the molecules could benefit astronauts, pilots and passengers of high-altitude aircraft who are inordinately exposed to solar radiation. "It is possible that people regularly exposed to ionizing radiation, such as airline pilots, frequent fliers or people who handle radioactive materials, might take IP6 prophylactically to prevent possible long term effects of exposure," Shamsuddin said.

The study was reported today at the American Association for Cancer Research Centennial Conference on Translational Cancer Medicine.

Source: ANI
LIN/V
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Radiotherapy X-Ray Anti-ageing and Benefits of Red Wine Ultra-Violet Radiation Genetic Testing of Diseases Epigenetics Herbs and Antioxidants Mint It All! Quiz on Antioxidants 

Recommended Reading
Effects of Ultraviolet Radiation
Health concerns of Ultra Violet Radiation in humans need to be clearly understood to protect ......
Anti-Ageing and Benefits of Red Wine
Ageing process has always been an enigma. Recent research indicates that red wine could delay the .....
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Epigenetics
In the recent years ‘epigenetics’ represents inheritable changes in gene expression that do not incl...
Genetic Testing of Diseases
Genetic testing helps to confirm a genetic condition in an individual and involves q complex laborat...
Herbs and Antioxidants
Herbs are rich sources of anti-oxidants that help build your immune system. Reach out for your spice...
Mint It All!
A popular garden herb, mint has earned worldwide fame both in the kitchen as well as health. A tasty...
Radiotherapy
A detailed account of radiation, its mode of action, side effects and dosage in the treatment of ......
Ultra-Violet Radiation
Ultraviolet radiations are electromagnetic radiations with wavelengths shorter than the shortest wav...
X-Ray
Encyclopedia section of medindia gives a brief Overview of X-Ray  ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use