Taking a specially formulated antioxidant-enriched multivitamin may decrease respiratory illnesses in people with cystic fibrosis (CF). The study from Children's Hospital Colorado (Children's Colorado) and the University of Colorado School of Medicine is published in the American Journal of Respiratory and Critical Care Medicine.
The study looked at the effects of a 'cocktail' of multiple antioxidants on inflammation and health outcomes in patients with cystic fibrosis . Inflammation is an important contributor to lung damage in CF, and contributes to progressive lung function decline.
The 16-week study consisted of 73 pancreatic-insufficient CF patients ages 10 years and older (average age 22 years). These patients ordinarily do not adequately absorb important dietary antioxidants including carotenoids such as beta(Ģ])-carotene, tocopherols (vitamin E), coenzyme Q10 (CoQ10), and selenium that help to neutralize inflammation in the body. To address this issue, the antioxidants used in the study were delivered in a capsule specifically designed for individuals with difficulties absorbing fats and proteins, including those with CF.
Specifically, half as many of the patients taking the supplemental antioxidants experienced a pulmonary exacerbation (or respiratory illness) requiring antibiotics compared to the group taking the control multivitamin without added antioxidants at 16 weeks. In addition, the antioxidant treated group experienced a lower frequency of respiratory illnesses compared to the control group.
"Single oral antioxidant formulations have been previously tested in CF with mixed results. However, there had not been a well-designed, randomized controlled trial of an antioxidant 'cocktail' that included multiple antioxidants in a single formulation," said Scott D. Sagel, MD, PhD, pediatric pulmonologist at Children's Colorado and professor of pediatrics at the University of Colorado School of Medicine. "While more research certainly needs to be done to find a treatment that delivers a sustained anti-inflammatory effect, we believe the fact that this antioxidant supplement prolonged the time patients had before their first illness is meaningful. It offers a simple, relatively inexpensive means for restoring and maintaining normal antioxidant levels in people who would otherwise have trouble doing so."