About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Antioxidant-enriched Multivitamin Reduces Respiratory Problems in Cystic Fibrosis Patients

by Anjali Aryamvally on May 24, 2018 at 6:52 PM
Font : A-A+

Antioxidant-enriched Multivitamin Reduces Respiratory Problems in Cystic Fibrosis Patients

Taking a specially formulated antioxidant-enriched multivitamin may decrease respiratory illnesses in people with cystic fibrosis (CF). The study from Children's Hospital Colorado (Children's Colorado) and the University of Colorado School of Medicine is published in the American Journal of Respiratory and Critical Care Medicine.

The study looked at the effects of a 'cocktail' of multiple antioxidants on inflammation and health outcomes in patients with cystic fibrosis . Inflammation is an important contributor to lung damage in CF, and contributes to progressive lung function decline.

Advertisement


The 16-week study consisted of 73 pancreatic-insufficient CF patients ages 10 years and older (average age 22 years). These patients ordinarily do not adequately absorb important dietary antioxidants including carotenoids such as beta(Ģ])-carotene, tocopherols (vitamin E), coenzyme Q10 (CoQ10), and selenium that help to neutralize inflammation in the body. To address this issue, the antioxidants used in the study were delivered in a capsule specifically designed for individuals with difficulties absorbing fats and proteins, including those with CF.

Antioxidant supplementation was safe and well-tolerated. Supplemental antioxidants increased antioxidant concentrations in the bloodstream in treated subjects and temporarily reduced inflammation in the blood at four weeks but not 16 weeks. Importantly, antioxidant treatment appeared to both prolong the time to the first respiratory illness requiring antibiotics and reduce the frequency of respiratory illnesses they experienced.
Advertisement

Specifically, half as many of the patients taking the supplemental antioxidants experienced a pulmonary exacerbation (or respiratory illness) requiring antibiotics compared to the group taking the control multivitamin without added antioxidants at 16 weeks. In addition, the antioxidant treated group experienced a lower frequency of respiratory illnesses compared to the control group.

"Single oral antioxidant formulations have been previously tested in CF with mixed results. However, there had not been a well-designed, randomized controlled trial of an antioxidant 'cocktail' that included multiple antioxidants in a single formulation," said Scott D. Sagel, MD, PhD, pediatric pulmonologist at Children's Colorado and professor of pediatrics at the University of Colorado School of Medicine. "While more research certainly needs to be done to find a treatment that delivers a sustained anti-inflammatory effect, we believe the fact that this antioxidant supplement prolonged the time patients had before their first illness is meaningful. It offers a simple, relatively inexpensive means for restoring and maintaining normal antioxidant levels in people who would otherwise have trouble doing so."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Genetic Testing of Diseases Asbestosis Cystic Fibrosis Fibroscan for Fatty Liver Cirrhosis and Fibrosis Retroperitoneal Fibrosis / Ormondīs Disease 

Recommended Reading
Cystic Fibrosis Treatment Using an Enzyme That Activates Chloride
Activation of the chloride channel in the lungs could help in the functioning of the lungs in those ...
Cystic Fibrosis Treatment Made Effective With Quorum-sensing Inhibitors
By reducing the bacterial production of harmful residues using quorum-sensing inhibitors, drug ......
Overexpression of Mucus Genes in Obstructive Pulmonary Diseases
COPD lung epithelial cells have abnormalities in mRNA ligation, which, as a result, causes ......
Asbestosis
Asbestosis is a chronic inflammatory lung disease that occurs due to long term exposure to asbestos ...
Cystic Fibrosis
Cystic fibrosis is a genetic disease involving the mucus and sweat glands and the medical world has ...
Fibroscan for Fatty Liver Cirrhosis and Fibrosis
Recently, Fibroscan has incorporated the noninvasive Controlled Attenuation Parameter technique to e...
Genetic Testing of Diseases
Genetic testing helps to confirm a genetic condition in an individual and involves q complex laborat...
Retroperitoneal Fibrosis / Ormondīs Disease
Retroperitoneal fibrosis or Ormond's disease a rare disorder occurs when extra fibrous tissue forms ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use