An analysis of nine trials shows the drugs make no difference even if the patient has been ill for more than seven days.
Sinusitis is very common - often occurring after colds or flu.
The infection of the sinuses - small air pockets inside the cheekbones and forehead - causes a high temperature, pain and tenderness in the face and forehead, and a blocked or runny.
In the research, which looked at how long 2,600 patients were ill before they received treatment, found time of illness is not a good indicator of whether antibiotics will be effective.
Because of side-effects, costs, and the risk of resistance, antibiotics are not justified even if patients have been ill for longer than a week, the researchers concluded.
The figures showed 15 patients would need to be treated before one would be cured with antibiotics.
"If a patient comes to the GP and says they have had the complaint for seven to 10 days that's not a good enough reason for giving them the antibiotic," BBC quoted Study leader, Dr Jim Young, from the Basel Institute for Clinical Epidemiology in Switzerland, as saying.
Source: ANI
SUN/L