Medindia
Advertisement

Anti-hypertensive Drug Checks Multiple Sclerosis-related Brain Inflammation

by Rathi Manohar on July 30, 2010 at 4:27 PM
Font : A-A+

Anti-hypertensive Drug Checks Multiple Sclerosis-related Brain Inflammation

Antihypertensive drugs, using a new signalling pathway of brain cells, could control inflammation in multiple sclerosis (MS), say researchers in Heidelberg and Stanford.

The peptide angiotensin not only raises blood pressure but also activates the immunological messenger substance TGF beta on a previously unknown communication pathway in the brain, found study conducted by Stanford Professor Lawrence Steinman along with Heidelberg's Dr. Tobias Lanz and Dr. Michael Platten.

Advertisement

Angiotensin II is known as a molecule that regulates blood pressure.

Drugs that block the angiotensin receptors, (AT1R blockers) are prescribed to millions of people to lower high blood pressure.

These are immune cells that are involved in autoimmune reactions and chronic-inflammatory diseases such as MS.
Advertisement

MS is characterized by multifocal areas of inflammation in the brain and spinal cord that lead to paralysis and other neurological symptoms.

The scientists working with Professor Platten showed in a mouse model that angiotensin II promotes inflammation in the brain and spinal cord.

When the angiotensin receptors, i.e. the sites where angiotensin docks onto cells and can develop its effect, were blocked by the orally administered blood pressure drug Candesartan, the inflammation decreased and the paralysis resolved.

"Since AT1R blockers are frequently prescribed for lowering blood pressure and have a proven safety profile, it is an obvious step to test them soon in MS patients. Of course, in research it is important to search for specific drugs with new molecular targets. But in our study, we show that approved medications can also be successfully studied for benefits in other diseases. The potential use of these generic drugs with a proven safety profile would also have a great impact on reducing healthcare costs," said Platten.

The researchers know that angiotensin transfers its information to the cell via an increase in the messenger substance Transforming Growth Factor beta (TGF beta).

Such a "network pathway" between angiotensin and TGF beta was previously unknown in the brain. TGF beta can have completely opposite effects - on the one hand it regulates and alleviates inflammatory reactions, but in other situations it causes inflammation and promotes it.

Which function the factor has depends on the surrounding tissue and the interaction with other messenger substances.

With respect to the whole body, TGF beta appears to protect the organism from inflammation and autoimmune diseases.

However, paradoxically, blockage of TGF beta production in the brain leads to a reduction of inflammation and thus to an improvement in symptoms.

"AT1R blockers prevent only the peak concentrations of TGF beta in the brain triggered by angiotensin, which are responsible for the inflammatory reaction. The baseline levels of TGF beta are not affected, so that the protective function for the rest of the body is apparently sustained," explained Platten.

The study is published in the "Journal of Clinical Investigation".

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Parkinsons Disease Parkinsons Disease Surgical Treatment Signature Drug Toxicity Brain Brain Facts Ataxia Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) 

Recommended Reading
Multiple Sclerosis
Multiple sclerosis can be a severely disabling autoimmune disease that affects the myelin or ......
Damage from Multiple Sclerosis Measured With Simple, Painless Eye Test
Researchers from UT Southwestern Medical Center claim that a quick, painless eye measurement shows ....
Cancer Drug may be Useful in the Treatment of Arthritis, Multiple Sclerosis
A drug which is currently used to treat cancer may assist in the treatment of a range of ......
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Ways to Improve your Intelligence Quotient (IQ)
Intelligence quotient (IQ) is a psychological measure of human intelligence. Regular physical and me...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use