Fluconazole, the commonly used oral anti-fungal to treat vaginal yeast infections, is related to higher rates of miscarriage if used during pregnancy, according to new research published in CMAJ (Canadian Medical Association Journal).
While topical treatments are the first line for pregnant women with fungal infections, oral fluconazole is often used during pregnancy.
Researchers looked at data on 441 949 pregnancies from the Quebec Pregnancy Cohort between 1998 and 2015, linking to filled prescriptions listed in the Quebec Prescription Drug Insurance database. They found that taking oral fluconazole was linked to adverse outcomes.
The study is consistent with other studies, although more research is needed as the study sizes are still small.
In a related commentary http://www.cmaj.ca/lookup/doi/10.1503/cmaj.190079, Drs. Vanessa Paquette and Chelsea Elwood, British Columbia Women's Hospital and Health Centre, Vancouver, BC, write, "The study re-emphasizes safe prescribing practices in pregnancy, which include confirming the correct diagnosis and then choosing the safest medication with the largest body of data in pregnancy at the lowest appropriate doses.