Another Treatment Target for Brain Tapeworm Infection Found

by Rishika Gupta on  December 2, 2017 at 12:57 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

Treating tapeworm larvae infection called Neurocysticercosis (NCC) in brain can sometimes lead to inflammation and seizures after the death of the pathogens. In the study published in PLOS Neglected Tropical Diseases journal, pre treatment with the anti-tumor necrosis factor drug etanercept (ETN) can help bring down the post-treatment inflammation.
Another Treatment Target for Brain Tapeworm Infection Found
Another Treatment Target for Brain Tapeworm Infection Found

NCC, which is caused by the parasitic cestode Taenia solium, is a major cause of epilepsy in developing countries around the world. While treatments exist to kill the parasite, degenerating cysts in the brain provoke inflammatory responses that can cause a variety of neurological problems.

Show Full Article


Currently, physicians typically use cortico-steroids to control this inflammatory response, but this comes at a high cost of severe side effects with long courses of treatment at high doses. Basic research has suggested that other anti-inflammatory drugs including the tumor necrosis factor TNF-α blockers may suppress some pathways involved in the treatment-induced inflammation.

In the new work, Siddhartha Mahanty of the National Institute of Allergy and Infectious Diseases, and colleagues from Universidad Peruana Cayetano Heredia in Lima, Peru, used pigs naturally infected with NCC to compare different treatment regiments.

One group of pigs received the cysticidal drug praziquantel (PZQ) alone; another received PZG preceded by two doses of the TNF-α blocker ETN; a third received PZG as well as three doses of the steroid dexamathasone (DEX); and the last group was given no treatment.

Treatment with ETN before PZQ inhibited the levels of a number of genes known to regulate inflammation. The same degree of changes to gene levels were not seen in the other groups. The degree of inflammation was modestly decreased in both ETN and DEX pretreated animals. In addition, scores of cyst wall damage showed that pretreatment with ETN, unlike DEX, did not inhibit the damage to cysts caused by PZQ.

"ETN, a licensed biologic, has been used for TNF-α blockade for over 20 years and has shown remarkable efficacy as an anti-inflammatory agent in rheumatoid arthritis and inflammatory bowel diseases; its safety profile is well known," the researchers say.

"Our data demonstrate that TNF-α blockade induces potent suppression of post-treatment pericystic inflammation in a natural infection model of NCC."

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Recommended Reading

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Premium Membership Benefits

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive