About Careers MedBlog Contact us

Ancient DNA Reveals Genetic Legacy of Pandemics

by Bidita Debnath on December 20, 2016 at 11:19 PM
Font : A-A+

 Ancient DNA Reveals Genetic Legacy of Pandemics

For populations of Prehistoric America, tuberculosis, treponemal disease, Chagas disease, and many other pathogens were endemic. But the "Columbian Exchange" beginning in 1492 introduced new pathogens to American populations, including smallpox, measles, influenza, and yellow fever.

This introduction had devastating consequences for tribes. Infectious diseases resulted in the depopulation of complete regions, leading to the collapse of social, economic, and political institutions, and the loss of many traditional cultural practices and ways of life.


The dynamics of these pandemics is critical to learn how they have shaped the genetic diversity of contemporary Native American communities, giving insights into the genetic foundations of diseases present in a higher frequency in some populations than elsewhere. Documenting the historical effects of the introduction of novel pathogens can give insights into the evolution of host-pathogen relationships, useful for responding to future outbreaks of emerging infectious diseases, The Guardian has reported.

Hypotheses have suggested that years of separation and independent evolution from Old World populations rendered the indigenous inhabitants of the Americas immunologically susceptible to the pathogens. The resulting outbreaks of disease - the so-called "virgin soil epidemics" - following first exposure to these pathogens were, thus, devastating. But many of these diseases leave no trace of infection in skeletons, making it impossible to fully test this model using only osteological approaches.

However, our ability to recover DNA from past populations gives us a way to document the evolutionary effects of these pandemics.

Source: ANI

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Ancient DNA Reveals Genetic Legacy of Pandemics Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests