Amino Acid Profile Alterations in Children With ADHD

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder in children. The disorder affects normal behavior and impairs the ability to concentrate.

ADHD is manifested at the neurochemical level as a disruption in dopamine and norepinephrine, but there is no definitive data about the role of amino acids profile changes in brain function.

Mindfulness-Based Intervention For ADHD
Children with ADHD treatment with mindfulness-based intervention (MBI) considering the mental health of parents can be effective for psychological symptoms and behavior of children and parents.

‘Detecting amino acid profile alterations in children with attention deficit hyperactivity disorder (ADHD) reveals new treatment strategies.’

Tweet it Now

A recent study by RUDN University doctors published in the journal Biomedical Reports shows that alterations in serum amino acid profile in children with attention deficit hyperactivity disorder (ADHD) help to understand the mechanism of the disorder and develop new treatment strategies.

"Amino acids serve a significant role in brain development and functioning. In particular, certain amino acids or their precursors are well-established to be involved in neuronal signaling as neurotransmitters. Correspondingly, disruption of amino acid metabolism results in significant neurological disorders, particularly in children”, says Anatoly Skalny, DSc, Head of RUDN Department of medical elements studies.

This study involves measuring amino acids level in the blood serum of 102 children aged 7 to 14 years with 71 of them were diagnosed with ADHD and the rest of the participants were neurotypical (without diagnosed disorders).

Heavy Use of Digital Media May Up Risk of ADHD in Teenagers
Increase in the use of digital media puts teenagers at risk of developing attention-deficit/hyperactivity disorder, says study.

The results of the study show that the serum amino acid profile in children with ADHD differs from neurotypical children. Histidine, glutamine, and proline levels were lower and aspartic acid, glutamate and hydroxyproline were higher.

The ratio of glutamine to glutamate in children indicating the transmission of nerve impulses and the ratio of proline to hydroxyproline, a marker of disorders of collagen metabolism and connective tissue are lower in ADHD children.

Adult Attention-Deficit Hyperactivity Disorder (ADHD)
Adult attention-deficit hyperactive disorder (ADHD) is a mental health condition in adults seen as hyperactivity, impulsiveness and reduced attention. ADHD impairs social, academic, neuropsychological and occupational behavior.

Therefore, understanding the potential underlying mechanisms implicated in ADHD pathogenesis is essential for the development of management strategies in the future.

Quiz on ADHD
Attention Deficit/Hyperactivity Disorder (AD/HD, generally abbreviated as ADHD) is considered a “neurobehavioral developmental disorder”. To know what this definition means and what the causes, symptoms and treatment for ADD are; give our ADHD quiz your best shot.

Source-Medindia