Amino Acid Profile Alterations in Children With ADHD

Alterations in serum amino acid profile in children with attention deficit hyperactivity disorder (ADHD) help to understand the mechanism of the disorder for developing new treatment strategies.

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder in children. The disorder affects normal behavior and impairs the ability to concentrate.

ADHD is manifested at the neurochemical level as a disruption in dopamine and norepinephrine, but there is no definitive data about the role of amino acids profile changes in brain function.

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‘Detecting amino acid profile alterations in children with attention deficit hyperactivity disorder (ADHD) reveals new treatment strategies.’

A recent study by RUDN University doctors published in the journal Biomedical Reports shows that alterations in serum amino acid profile in children with attention deficit hyperactivity disorder (ADHD) help to understand the mechanism of the disorder and develop new treatment strategies.

"Amino acids serve a significant role in brain development and functioning. In particular, certain amino acids or their precursors are well-established to be involved in neuronal signaling as neurotransmitters. Correspondingly, disruption of amino acid metabolism results in significant neurological disorders, particularly in children”, says Anatoly Skalny, DSc, Head of RUDN Department of medical elements studies.

This study involves measuring amino acids level in the blood serum of 102 children aged 7 to 14 years with 71 of them were diagnosed with ADHD and the rest of the participants were neurotypical (without diagnosed disorders).

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The results of the study show that the serum amino acid profile in children with ADHD differs from neurotypical children. Histidine, glutamine, and proline levels were lower and aspartic acid, glutamate and hydroxyproline were higher.

The ratio of glutamine to glutamate in children indicating the transmission of nerve impulses and the ratio of proline to hydroxyproline, a marker of disorders of collagen metabolism and connective tissue are lower in ADHD children.

Adult Attention-Deficit Hyperactivity Disorder (ADHD)
Adult attention-deficit hyperactive disorder (ADHD) is a mental health condition in adults seen as hyperactivity, impulsiveness and reduced attention. ADHD impairs social, academic, neuropsychological and occupational behavior.

Therefore, understanding the potential underlying mechanisms implicated in ADHD pathogenesis is essential for the development of management strategies in the future.

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Source-Medindia