Reversing the formation of amyloid plaques in the brain can reduce the risk of Alzheimer's disease and improve cognitive function. Gradually depleting an enzyme called BACE1 can completely reverse the formation of amyloid plaques -- protein fragments that the body produces normally.
‘Decreasing the activity of BACE1 reduces beta-amyloid peptide levels and the risk of Alzheimer's disease.’Drugs targeting this enzyme will be able to successfully treat Alzheimer's in humans, the researchers said.
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"Our study provides genetic evidence that preformed amyloid deposition can be completely reversed after sequential and increased deletion of BACE1 in the adult," said Riqiang Yan from the Cleveland Clinic Lerner Research Institute in Ohio.
Abnormal buildup of beta-amyloid peptide, which can form large amyloid plaques in the brain and disrupt the function of neuronal synapses, is one of the earliest events in Alzheimer's.
For the study, published in the Journal of Experimental Medicine, the team generated mice that gradually lose this enzyme as they grow older.
These mice developed normally and appeared to remain perfectly healthy over time. Then researchers bred these rodents with mice that start to develop amyloid plaques and Alzheimer's when they are 75 days old.
Remarkably, the plaques began to disappear as the mice continued to age and lose BACE1 activity, until, at 10 months old, the mice had no plaques in their brains at all.
Loss of BACE1 also improved the learning and memory of mice with Alzheimer's. However, electrophysiological recordings of neurons from these animals showed that depletion of BACE1 only partially restored synaptic function, suggesting that BACE1 may be required for optimal synaptic activity and cognition, Yan said.