Acute systemic toxicity testing in animals is required by various
regulatory agencies and involves exposing animals to a test substance
orally, dermally, or via inhalation, then counting the number of animals
who died as a result.
More than 60 experts from regulatory agencies,
industry, academia, and NGOs attended the September 2015 workshop to
discuss alternatives to these tests that better protect human health and
do not use animals.
‘The alternative approaches discussed at the workshop will allow researchers to assess human toxicity more rapidly and accurately while also reducing costs and not harming animals.’
A report outlining the findings of the international expert workshop
"Alternative Approaches for Identifying Acute Systemic Toxicity: Moving
From Research to Regulatory Testing" was published in the journal Toxicology In Vitro
The workshop focused on developing a strategy for reducing and
replacing the use of animals in acute systemic toxicity testing, and
recommendations included gathering high-quality reference data,
expanding education on the use and interpretation of animal-free test
methods, and global harmonization. Work to implement the recommendations
The workshop was held in September 2015 at the National Institutes
of Health in Bethesda, Maryland. It was co-hosted by the PETA
International Science Consortium, the NTP Interagency Center for the
Evaluation of Alternative Toxicological Methods (NICEATM), and the
Physicians Committee for Responsible Medicine.
Co-authors of the report include the Consortium, the Environmental
Protection Agency, the Consumer Product Safety Commission, the National
Institutes of Health's (NIH) National Center for Advancing Translational
Sciences, the European Union Reference Laboratory for Alternatives to
Animal Testing (EURL ECVAM), The Dow Chemical Company, Rutgers
University, and Utrecht University, among others.
Dr. Amy Clippinger, Associate Director of the Consortium, says, "The
alternative approaches discussed at the workshop will allow us to
assess human toxicity more rapidly and accurately while also reducing
costs and not harming animals."
Following the workshop, the Consortium and NICEATM co-sponsored an expert meeting focused on alternative approaches to acute inhalation toxicity testing in September 2016 in Bethesda, Maryland.