About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Alternative Way to Treat Klebsiella Pneumoniae Infections Found

by Megha Ramaviswanathan on March 14, 2018 at 11:38 AM
Font : A-A+

Alternative Way to Treat Klebsiella Pneumoniae Infections Found

A new approach that uses antibodies to target Klebsiella pneumonia protective capsule polysaccharide can be a more promising alternative to antibiotic treatment for infections caused by K. pneumonia bacteria resistant to carbapenem antibiotics. The antibodies will allow the immune system cells called neutrophils to attack and kill the bacteria. The research done by scientists at National Institute of Allergy and Infectious diseases (NIH) is published in the journal mBio.

Advertisement


Klebsiella bacteria cause about 10 percent of all hospital-acquired infections in the United States. A carbapenem-resistant K. pneumonia strain known as multilocus sequence type 258 (ST258) is one of the antibiotic-resistant organisms labeled an urgent threat by the Centers for Disease Control and Prevention. ST258 is particularly concerning because it is resistant to most antibiotics. It is a significant cause of mortality among people with bloodstream infections.

The scientists first determined that the bacterial capsule prevents immune system neutrophils from ingesting and killing ST258. They then extracted capsule from the two most abundant capsule types of ST258 and used them to generate antibodies in rabbits. In cell culture experiments they found that one of the antibodies enhanced the ability of neutrophils to ingest and kill bacteria. These results are a "proof of concept" for a potential immunotherapy approach for treatment of multidrug-resistant K. pneumonia infections, the authors write.
Advertisement

Next up, the scientists will test the therapeutic concept in mice. They also will compare immunization with purified capsule polysaccharide as a preventive approach (active immunization) versus using capsule-specific antibodies as a therapy (passive immunization). Ultimately, they hope either antibody treatment alone or in combination with antibiotics could greatly improve care for people with multidrug-resistant K. pneumonia infections.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Pneumonia
Pneumonia is a lung infection that can be caused by a bacteria or a virus. It causes inflammation .....
New Vaccine Offers Universal Prevention from Pneumonia
New pneumonia vaccine provides the most comprehensive coverage to date and alleviates antimicrobial ...
Treat Pneumonia With Vaccines Instead of Antibiotics
There are significant differences between the lung and the upper respiratory tract in the immune ......
Debunking Myths on Hospital-Acquired Pneumonia
Seven in 10 non-ventilator hospital-acquired pneumonia cases were acquired outside of the ICU, ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use