New study highlights that allergic reactions may play a critical role in brain behavior development in unborn males and females. The findings of the study are published in the journal Scientific Reports.
A team of researchers at the University of Maryland School of Medicine and colleagues at Ohio State University have discovered that allergic reactions trigger changes in brain behavior development in unborn males and females. This latest brain development discovery will ultimately help researchers better understand how neurological conditions can differ between men and women.
Allergy
An allergy is a hypersensitive disorder of immune system. Substances that often cause allergic reactions are pollen, dust mites, mold spores, pet dander, food, insect stings and medicines.
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‘Allergic reactions may trigger changes in brain behavior development in unborn males and females. Early life allergic reactions may influence natural differences in both male and female sexual behavior, potentially through the underlying effects on brain-resident mast cells.’
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It is the first study to assess the response of a type of immune cell called a mast cell, linked to allergic responses, to determine if these cells play a role in sexual behavior development.
"Many mental health and neurological disorders show a sex bias in prevalence, this latest research shows that inflammatory events, like allergic reactions, early in life may influence males and females differently due to underlying sex differences in the neuroimmune system," said Margaret McCarthy, PhD, Professor of Pharmacology and Chair of the Department of Pharmacology, whose lab conducted the research that was initiated by Dr. Katherine Lenz, an Assistant Professor in the Department of Psychology at Ohio State University
![Types of Food Allergies]( "Types of Food Allergies")
These findings, illustrate that immune cells are involved in the process of brain sexual differentiation, and that prenatal allergic inflammation can impact this crucial process in both sexes. This finding is another discovery that will ultimately help researchers understand behavioral development differences between males and females.
How Allergic Reactions Impact Sexual Behavior
The research team tested the sexual differentiation in rats that were exposed to an allergic reaction while still in utero. They induced an allergic reaction to egg whites in pregnant rats, and the results of the study showed the allergic reaction impacted behavior changes in the offspring. Male rats showed less male sexual behavior as adults, and adult females behaved more like male rates.
The research tracked mast cells, which are known for their role in allergic responses. Researchers sought to determine if exposure to an allergic response of the pregnant female in utero would alter the sexual differentiation of the offspring and result in sociosexual behavior in later life.
"This research shows that early life allergic events may contribute to natural variations in both male and female sexual behavior, potentially via underlying effects on brain-resident mast cells," said Dr. McCarthy.
Sexual differentiation takes place in the early life process, and it is directed by sex chromosomes, hormones, and early life experiences. What this research showed is that immune cells residing in the brain such as microglia and mast cells, are more numerous in the male than female rat brains, and these cells play a critical role in brain development.
Source: Eurekalert
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These findings, illustrate that immune cells are involved in the process of brain sexual differentiation, and that prenatal allergic inflammation can impact this crucial process in both sexes. This finding is another discovery that will ultimately help researchers understand behavioral development differences between males and females.
How Allergic Reactions Impact Sexual Behavior
The research team tested the sexual differentiation in rats that were exposed to an allergic reaction while still in utero. They induced an allergic reaction to egg whites in pregnant rats, and the results of the study showed the allergic reaction impacted behavior changes in the offspring. Male rats showed less male sexual behavior as adults, and adult females behaved more like male rates.
The research tracked mast cells, which are known for their role in allergic responses. Researchers sought to determine if exposure to an allergic response of the pregnant female in utero would alter the sexual differentiation of the offspring and result in sociosexual behavior in later life.
"This research shows that early life allergic events may contribute to natural variations in both male and female sexual behavior, potentially via underlying effects on brain-resident mast cells," said Dr. McCarthy.
Sexual differentiation takes place in the early life process, and it is directed by sex chromosomes, hormones, and early life experiences. What this research showed is that immune cells residing in the brain such as microglia and mast cells, are more numerous in the male than female rat brains, and these cells play a critical role in brain development.
Source: Eurekalert
Allergy - Symptom Evaluation
An allergic reaction may be mild or severe. It usually involves the skin, respiratory system, eyes, digestive system or blood pressure.
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 New Treatment for Egg Allergy DiscoveredIn 75 percent of egg-allergic children, eating small amounts of egg every day for many months lowered the threshold for allergic reactions, say researchers. | Advertisement
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