About Careers MedBlog Contact us

Alcohol Allows Gut Bacteria to Infiltrate into Liver: Study

by Bidita Debnath on February 13, 2016 at 2:24 AM
Font : A-A+

 Alcohol Allows Gut Bacteria to Infiltrate into Liver: Study

Alcohol allows gut bacteria to migrate to the liver, promoting alcohol-induced liver diseases, reveals a new study from University of California, in the US.

According to the researchers, natural gut antibiotics are diminished by alcohol and leave mice more prone to bacterial growth in the liver, exacerbating alcohol-induced liver disease. "Alcohol appears to impair the body's ability to keep microbes in check," said senior author Bernd Schnabl from University of California, San Diego School of Medicine in the US.


"When those barriers breakdown, bacteria that don't normally colonise the liver end up there, and now we've found that this bacterial migration promotes alcohol liver disease. Strategies to restore the body's defenses might help us treat the disease," Schnabl added.

The study was published in Cell Host & Microbe. REG3G deficiency promotes progression of alcohol-induced liver disease. For the study, mice engineered to lack REG3G and fed alcohol for eight weeks were more susceptible to bacterial migration from the gut to the liver than normal mice who received the same amount of alcohol, the researchers discovered.

REG3G-deficient mice also developed more severe alcoholic liver disease than normal mice. To find methods for stemming the tide of liver-damaging microbes, researchers tried experimentally bumping up copies of the REG3G gene in intestinal lining cells grown in the lab.

They found that more REG3G reduced bacterial growth. Likewise, restoring REG3G in mice protected them from alcohol-induced fatty liver disease, a condition that precedes liver cirrhosis, or end-stage liver disease. Not only do patients with alcohol dependency have lower levels of REG3G than healthy people, they also have more bacteria growing there, the study found.

Source: IANS


Recommended Reading

Latest Research News

Brain Region Linking Short-term to Long-term Memory Discovered
The model for memory consolidation claims that the hippocampus forms new memories and, as time goes on, trains the cortex to store enduring memories.
What Are the Effects of T Cells on Blood Pressure and Inflammation?
A new study explored the link between T immune cells in ill patients and mortality risk.
How Does a New Procedure Help Patients Avoid Leg Amputation?
Limb savage procedure benefits patients with severe vascular disease who are at risk for amputation of their limbs.
Omega-3 Can Save Alzheimer's Patients from Vision Loss
Does omega-3 help Alzheimer's patients? A new form of omega-3 helped restore specific markers of eye health in mice bred with aspects of early-onset Alzheimer's disease.
Why Is Asthma Linked to Increased Risk of Osteoarthritis?
Drugs used to inhibit the physiological responses for allergic reactions lessen osteoarthritis risk, revealed research.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Alcohol Allows Gut Bacteria to Infiltrate into Liver: Study Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests