Aerobic exercise breaks down estrogens to produce more of the good metabolites that lower the risk of breast cancer, finds research.
Observational studies suggest physical activity lowers breast cancer risk, but there are no clinical studies that explain the mechanism behind this, said Mindy S. Kurzer, Ph.D., professor in the Department of Food Science and Nutrition at the University of Minnesota in Saint Paul.
Exercise
It is important for us to understand the power of daily exercise. Only then can we motivate ourselves to inculcate the habit of exercise on a daily basis.
Advertisement
Kurzer and her colleagues conducted the Women in Steady Exercise Research (WISER) clinical trial, which involved 391 sedentary, healthy, young, premenopausal women. They randomly assigned the women to two age-matched, body mass index-matched groups: a control group of 179 women and an intervention group of 212 women.
While women in the control group continued a sedentary lifestyle for the entire study period, women in the intervention group performed 30 minutes of moderate-to-vigorous aerobic exercise five times a week for 16 weeks. Aerobic exercises included the treadmill, stair stepper or elliptical machine.
![Breast Cancer Screening using Mammogram]( "Breast Cancer Screening using Mammogram")
Breast cancer if detected early can be completely cured. Mammography is used to screen women for breast cancer.
Using a state-of-the-art technique called liquid chromatography/tandem mass spectroscopy, they measured the amount of three parent estrogens, E1, E2 and E3, and nine of their breakdown products called metabolites, in the participants' urine samples.
According to Kurzer, estrogen metabolism favoring the production of a metabolite called 2-hydroxyestrone (2-OHE1) over one called 16alpha-hydroxyestrone (16alpha-OHE1), which results in an increase in the 2-OHE1/16alpha-OHE1 ratio, has been linked with a reduction in breast cancer risk.
She and her colleagues found that aerobic exercise led to an increase in the amount of 2-OHE1 and a decrease in the amount of 16alpha-OHE1, which led to a significant increase in the 2-OHE1/16alpha-OHE1 ratio. There were no changes in the 2-OHE1/16alpha-OHE1 ratio in the urine of control group participants.
"Exercise, known to favor fitness and improve heart health, is also likely to help prevent breast cancer by altering estrogen metabolism," said Kurzer.
In collaboration with researchers at the University of Pennsylvania in Philadelphia, Kurzer is conducting similar studies in women with a high risk for breast cancer.
The study results were published in Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research.
Source: ANI
Breast Cancer Screening using Mammogram
Breast cancer if detected early can be completely cured. Mammography is used to screen women for breast cancer.
Advertisement
Using a state-of-the-art technique called liquid chromatography/tandem mass spectroscopy, they measured the amount of three parent estrogens, E1, E2 and E3, and nine of their breakdown products called metabolites, in the participants' urine samples.
According to Kurzer, estrogen metabolism favoring the production of a metabolite called 2-hydroxyestrone (2-OHE1) over one called 16alpha-hydroxyestrone (16alpha-OHE1), which results in an increase in the 2-OHE1/16alpha-OHE1 ratio, has been linked with a reduction in breast cancer risk.
She and her colleagues found that aerobic exercise led to an increase in the amount of 2-OHE1 and a decrease in the amount of 16alpha-OHE1, which led to a significant increase in the 2-OHE1/16alpha-OHE1 ratio. There were no changes in the 2-OHE1/16alpha-OHE1 ratio in the urine of control group participants.
"Exercise, known to favor fitness and improve heart health, is also likely to help prevent breast cancer by altering estrogen metabolism," said Kurzer.
In collaboration with researchers at the University of Pennsylvania in Philadelphia, Kurzer is conducting similar studies in women with a high risk for breast cancer.
The study results were published in Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research.
Source: ANI
Quiz on Fitness
Who wouldn't want to look fit in the current scenario where young and old are hitting the gym to look and feel fighting fit? We invite you to participate in this quiz on fitness and check if you are well informed on what it takes to remain fit all through your life.
Advertisement
 Breast Self Examination - AnimationSlides and animation of Breast Self Examination for early detection of breast cancer lumps in women | Advertisement
|
Advertisement
Recommended Reading
Latest Cancer News
Comprehending the association between the gut microbiome and polyp growth sheds insights into potential screenings and treatments.
The first large-scale, collaborative, open analysis of genomic data provides a cloud-based resource for researchers looking for more comprehensive data on pediatric brain tumors.
The mission of Axiom Space incorporated numerous experiments focusing on human stem cell aging, inflammation, and cancer within the laboratory situated in the low Earth orbit.
Providing a sustained supply of hydrogen sulfide to cancer cells, could be a remodeling strategy to improve photothermal therapy efficacy while minimizing side effects.
Colon cancer's hidden link revealed in microbiome study.