An Indian-origin researcher at Virginia Commonwealth University School of Medicine in Richmond, US, has announced the identification of a gene that is found in high levels in tumour samples from patients with Hepatocellular carcinoma (HCC)-a highly aggressive form of liver cancer-and generates a protein important for the progression of the disease.
Devanand Sarkar and his colleagues say that targeting the gene AEG1, or the protein it generates, may provide a new therapeutic strategy for the treatment of HCC.
Liver Cancer - Types, Causes, Symptoms, Diagnosis, Treatment, Prevention, Progosis
Liver or hepatic cancer is an abnormal growth of cells in the liver. The leading cause of the disease is cirrhosis or scarring of the liver tissue.
Liver or hepatic cancer is an abnormal growth of cells in the liver. The leading cause of the disease is cirrhosis or scarring of the liver tissue.
According to them, that was associated with an increase in the number of copies of the AEG1 gene in human HCC tumour samples.
Sarkar said that human liver cell lines engineered to over-express AEG1 grew faster than non-engineered cells, and developed into highly aggressive tumours when transplanted into mice.
Liver Cancer
Liver is the largest organ inside the human body. It performs 500 different functions and processes 720 liters of blood per day. The important functions of the liver, the development of liver cancer and it’s symptoms are presented in this interactive.
Liver is the largest organ inside the human body. It performs 500 different functions and processes 720 liters of blood per day. The important functions of the liver, the development of liver cancer and it’s symptoms are presented in this interactive.
Further analysis revealed that the effects of AEG1 were mediated, in part, via its ability to activate the Wnt signaling pathway.
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