Advantages of Decellularized Muscle Grafts Revealed

Study reported less scar tissue formation and more new neuromuscular receptors using a decellularized muscle matrix than either a rat muscle autograft or collagen plugs to repair large muscle defects. The findings of the study are published in Tissue Engineering, Part A, peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Tissue Engineeringwebsite until June 4, 2018.

The article entitled "Decellularized Muscle Supports New Muscle Fibers and Improves Function Following Volumetric Injury" was coauthored by Barbara Boyan, PhD, Virginia Commonwealth University (VCU), Richmond and Georgia Institute of Technology, Atlanta and colleagues from VCU and Musculoskeletal Transplant. Foundation, Edison, NJ and University of Texas Health Science Center at San Antonio.

Graft versus Host Disease (GvHD) - Types, Causes, Symptoms, Diagnosis, Treatment, Prevention & Prognosis
Graft versus host disease (GvHD) occurs when donor cells recognize the host cells as foreign and begin to attack it. Symptoms can be mild, severe or even fatal.

‘Compared to an autologous muscle graft, a decellularized muscle matrix used to repair medium- and large-sized defects in rats resulted in enhanced muscle function recovery, muscle regeneration, and the formation of new neuromuscular junctions.’

Tweet it Now

"This article demonstrated the potential of decellularized tissue grafts for use as scaffolds in tissue engineering applications," says Tissue Engineering Co-Editor-in-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX.

Source-Eurekalert

Muscle Regeneration Could be Possible With Nuclear Receptor REV-ERB
A nuclear receptor called REV-ERB can stimulate muscle regeneration upon acute muscle injury in an animal model.

A Stem Cell 'Prox1' Gene Commands Skeletal Muscle Regeneration
Skeletal muscle stem cells called satellite cells also express the Prox1 gene, revealed a new study.

Mechanically-Driven Therapies Effective in Promoting Skeletal Muscle Regeneration
Mechanically-driven therapies that promote skeletal muscle regeneration through direct physical stimulation could replace cell-based regenerative treatments.