In the last decade, the use of stem cell therapy in animals and
humans has dramatically increased. In dogs, stem cell therapy is used in
the treatment of a variety of orthopedic diseases and injuries. Stem
cells are harvested from either fat tissue or bone marrow, purified and
grown in culture, then placed back in the patient.
Given the ease of harvesting, adipose tissue has become the site of
most stem cell collections in canine patients. But questions persisted
regarding the differences between these two sources of stem cells, and
which is better suited to therapeutic applications.
‘Adipose (fat) stem cells might be the preferred stem cell type for use in canine therapeutic applications, including orthopedic diseases and injury.’
An international team of researchers, funded by Morris Animal
Foundation, has shown that adipose (fat) stem cells might be the
preferred stem cell type for use in canine therapeutic applications,
including orthopedic diseases and injury.
Researchers at the University of Guelph, University of Western
Ontario and Aarhus University, Denmark, ran a battery of tests comparing
the physiology characteristics of stem cells derived from adipose
tissue versus bone marrow.
They found that stem cells from both sources
had similar functional properties, including tissue generation and
immunomodulating capabilities (ability to adjust immune response), but
adipose stem cells grow at a faster rate than bone marrow stem cells.
Harvesting adipose stem cells also is less invasive than harvesting bone
The study recently was published in PLoS ONE
, an online scientific journal.
"Faster proliferation along with the potential for a less invasive
method of their procurement makes them (adipose stem cells) the
preferred source for canine mesenchymal stem cells," concluded the