In the last decade, the use of stem cell therapy in animals and
humans has dramatically increased. In dogs, stem cell therapy is used in
the treatment of a variety of orthopedic diseases and injuries. Stem
cells are harvested from either fat tissue or bone marrow, purified and
grown in culture, then placed back in the patient.
Given the ease of harvesting, adipose tissue has become the site of most stem cell collections in canine patients. But questions persisted regarding the differences between these two sources of stem cells, and which is better suited to therapeutic applications.
An international team of researchers, funded by Morris Animal Foundation, has shown that adipose (fat) stem cells might be the preferred stem cell type for use in canine therapeutic applications, including orthopedic diseases and injury.
They found that stem cells from both sources had similar functional properties, including tissue generation and immunomodulating capabilities (ability to adjust immune response), but adipose stem cells grow at a faster rate than bone marrow stem cells. Harvesting adipose stem cells also is less invasive than harvesting bone marrow.
The study recently was published in PLoS ONE, an online scientific journal.
"Faster proliferation along with the potential for a less invasive method of their procurement makes them (adipose stem cells) the preferred source for canine mesenchymal stem cells," concluded the research team.