A new study has revealed that cognitive and psychiatric impairments are common among long-term survivors of acute lung injury (ALI).

"We found that neuropsychological function can be assessed by telephone in a multi-center trial, and that long-term neuropsychological impairment is common in these patients," continued Dr. Mikkelsen. "We also found that hypoxemia was associated with an increased risk for long-term cognitive and psychiatric impairment."
The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
The test battery was administered to study subjects at two and 12 months after discharge from the hospital. At 12 months, memory, verbal fluency, and executive function (a set ofcognitive abilities necessary for effective daily functioning) were impaired in 13, 16, and 49 percent of survivors, respectively, while cognitive impairment (defined as impairment in memory, verbal fluency, and/or executive function) was found in 41 of 75 survivors (55 percent). Depression, post-traumatic stress disorder, and anxiety were found in 36, 39, and 62 percent of long-term survivors.
Enrollment in a conservative fluid-management strategy was significantly associated with the development of cognitive impairment, and lower partial pressure of arterial oxygen during the trial was associated with a significantly increased risk of both cognitive and psychiatric impairment. "Although it is plausible that use of a conservative fluid-management strategy was associated with an increased risk for long-term cognitive impairment," Dr. Mikkelsen said, "based on the small sample size and an unclear mechanism, this finding warrants confirmation."
The study had a few limitations, including its small sample size and the use of self-report for several measures.
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