Our kidney is responsible for retaining essential proteins and removing waste products from the blood stream.
Injury to the kidney results in loss of kidney filter function, which if not treated promptly, can induce kidney failure. In this issue of the Journal of Clinical Investigation, Anna Greka and colleagues at Massachusetts General Hospital determined that mice lacking the ion channel TRPC5 were protected from losing kidney filter function following kidney injury.
In the absence of TRPC5, kidney podocytes did not undergo any cytoskeletal remodeling, which kept the filtration barrier in tact. Furthermore, the authors demonstrated that pharmacological inhibition of TRPC5 protects animals from protein loss in the urine following kidney injury.