Medindia
Advertisement

Activation of Ion Channel Limits Injury-Induced Loss of Kidney Filtration

by Bidita Debnath on November 10, 2013 at 11:13 PM
Font : A-A+

 Activation of Ion Channel Limits Injury-Induced Loss of Kidney Filtration

Our kidney is responsible for retaining essential proteins and removing waste products from the blood stream.

Injury to the kidney results in loss of kidney filter function, which if not treated promptly, can induce kidney failure. In this issue of the Journal of Clinical Investigation, Anna Greka and colleagues at Massachusetts General Hospital determined that mice lacking the ion channel TRPC5 were protected from losing kidney filter function following kidney injury.

Advertisement

In the absence of TRPC5, kidney podocytes did not undergo any cytoskeletal remodeling, which kept the filtration barrier in tact. Furthermore, the authors demonstrated that pharmacological inhibition of TRPC5 protects animals from protein loss in the urine following kidney injury.

This study indicates that activation of ion channel TRPC5 following kidney injury promotes loss of kidney filter function, and inhibition of this ion channel may have therapeutic potential.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis Kidney Biopsy Prevention of Kidney Disease 

Recommended Reading
Kidney Disease Patients may Benefit from New Clinical Studies
New clinical trials have emphasized on potential therapies for kidney disease...
Gene Speeds Up Spread of Kidney Disease in African-Americans
African-Americans having a gene variant and chronic kidney disease are at double the risk of kidney ...
Soft Drinks and Sugar in the Diet may Have Negative Effects on the Kidneys
The potential negative effects that soft drinks and sugar can have on kidney health have been ......
New Study Links Kidney Damage in First Responders to 9/11
Researchers have linked high levels of inhaled particulate matter by first responders at Ground ......
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Prevention of Kidney Disease
Kidney damage is usually detected at advanced stages. Healthy lifestyle, keeping diabetes and blood ...
Renal Tubular Acidosis
Renal tubular acidosis/RTA results in acid content of the blood being higher than normal and that of...
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain ca...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use