A novel compound was used by researchers to exploit an Achilles' heel in the bacterium that causes tuberculosis.
In a series of laboratory experiments, the researchers have shown that it is possible to kill Mycobacterium tuberculosis by inhibiting ClpP, a cellular enzyme that is not targeted by any antibacterial drug on the market.
New Compound More Effective at Killing Tuberculosis
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Lead researcher Jason Sello, associate professor of chemistry at Brown, said that ClpP has emerged over the last decade or so as a potential drug target in bacteria because they require it to either live or to cause disease.
He said that their findings indicate that chemical inhibition of the essential ClpP enzyme in Mycobacterium tuberculosis is a viable strategy in anti-tuberculosis drug development.
![Researchers Discover Tuberculosis Genomes in 200-year Old Hungarian Mummy]( "Researchers Discover Tuberculosis Genomes in 200-year Old Hungarian Mummy")
Tuberculosis (TB) genomes were recovered from the lung tissue of a 215-year old mummy using a technique known as metagenomics, by researchers at the University of Warwick.
It degrades and eliminates proteins inside the cell that are misfolded, damaged, or have outlived their usefulness. While ClpP is dispensable in most bacteria, previous research has shown that it is absolutely essential for the viability of M. tuberculosis.
When the gene that makes the protein is knocked out of the bacterium's genome, the organism cannot survive.
The paper has been published online by journal ACS Chemical Biology.
Source: ANI
Researchers Discover Tuberculosis Genomes in 200-year Old Hungarian Mummy
Tuberculosis (TB) genomes were recovered from the lung tissue of a 215-year old mummy using a technique known as metagenomics, by researchers at the University of Warwick.
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It degrades and eliminates proteins inside the cell that are misfolded, damaged, or have outlived their usefulness. While ClpP is dispensable in most bacteria, previous research has shown that it is absolutely essential for the viability of M. tuberculosis.
When the gene that makes the protein is knocked out of the bacterium's genome, the organism cannot survive.
The paper has been published online by journal ACS Chemical Biology.
Source: ANI
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