By fully elucidating the role of serotonin in the brain, new study may contribute to a better understanding of the development or treatment of these conditions.

‘Now we have new insight into how the brain becomes wired and sensitive to changing serotonin levels.’

"For the first time, we can provide a complete description of an animal model from genes to behavior--including at the level of neuronal network activity, which has been ignored in most studies to date." 




Dr. Galán and his team used high-density multi-electrode arrays in a mouse model of serotonin deficiency to record and analyze neuronal activity. The study supports the importance of the serotonin which is specified and maintained by a specific gene, the Pet-1 gene - for normal functioning of the neurons, synapses and networks in the cortex, as well as proper development of brain circuitry.
Serotonin abnormalities have been linked to autism and epilepsy, depression and anxiety. By more fully elucidating the role of serotonin in the brain, this study may contribute to a better understanding of the development or treatment of these conditions. "By looking at the circuit level of the brain, we now have new insight into how the brain becomes wired and sensitive to changing serotonin levels." added Dr. Galán.
Source-Eurekalert