A new research shows how the absence of an important tumor-suppressing protein gives rise to acute myeloid leukemia (AML).
CSHL Professor Scott W. Lowe. Ph.D., an Investigator of the Howard Hughes Medical Institute and colleagues found that disabling protein P53 combined with a genetic mutation caused cell proliferation.
Acute Myeloid Leukemia
Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving leukemia that affects both children and adults alike
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P53 has the ability to induce a cell to commit suicide (apoptosis) or to enter a quiescent state in which it can no longer multiply (senescence). So its absence causes a cell's "braking" system to be disabled.
"We showed that it has the ability to reinforce cell-fate and differentiation programs. In AML, p53 loss leads to cancer by disabling this reinforcement. The question we are now eager to answer is whether p53 has similar functions in other types of cancer," said Johannes Zuber, M.D.
The results are published in the July 1 issue of Genes and Development.
Source: ANI
The results are published in the July 1 issue of Genes and Development.
Source: ANI
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 Acute Lymphoblastic LeukemiaAcute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated. | Advertisement
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Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is considered as one of the 'good cancers'.
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