About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

A-type Lamins Intervene When Chromatin is Targeted

by Julia Samuel on January 8, 2015 at 4:22 PM
Font : A-A+

A-type Lamins Intervene When Chromatin is Targeted

Regulation of gene activity is mainly concerned with nuclear organization.

The associations of the regulatory regions of the genome with the nuclear lamina have been identified.

Advertisement

Information about these lamina-associated domains (LADs) directed to the nuclear lamina is sparse.

Chromosomal insertion site system was used to identify small sequences from borders of fibroblast-specific variable LADs that are sufficient to target these ectopic sites to the nuclear periphery.
Advertisement

YY1 (Ying-Yang1) binding sites as enriched in relocating sequences were identified. There was no lamina association as lamina A was not knocked down like YY1 or lamin A/C.

In addition, targeted recruitment of YY1 proteins facilitated ectopic LAD formation dependent on histone H3 lysine 27 trimethylation and histone H3 lysine di- and trimethylation.

The results also reveal that endogenous loci appear to be dependent on lamin A/C, YY1, H3K27me3, and H3K9me2/3 for maintenance of lamina-proximal positioning.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Liver Transplantation
Organ Donation Week 2022 - 'Take the Pledge to Save Lives'
Test your Knowledge on Heart Transplantation
View all
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

Most Popular on Medindia

Accident and Trauma Care Post-Nasal Drip Drug Interaction Checker Diaphragmatic Hernia Nutam (400mg) (Piracetam) Calculate Ideal Weight for Infants Color Blindness Calculator The Essence of Yoga Blood Donation - Recipients Drug - Food Interactions
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use