About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

A Step to Unlocking Mystery of Ageing Taken By Swiss Researchers

by Rukmani Krishna on May 25, 2013 at 11:28 PM
Font : A-A+

 A Step to Unlocking Mystery of Ageing Taken By Swiss Researchers

A step closer to unlocking the mystery of ageing was taken by Swiss researchers after discovering the impact of a longevity gene in mice and then managing to extend the life-span of worms by 60 percent thanks to a basic antibiotic treatment.

"They were not only living longer, but were also more fit," said Johan Auwerx ion a video released by the Ecole Polytechnique Federale de Lausanne (EPFL), a cutting-edge Swiss research institute.

Advertisement

The findings of Auwerx's team have been published in the scientific journal Nature.

The goal of the research was to work out why certain individuals of the same species can have a far longer life-span than others.

"Our lab has for some time been using a complex genetic reference population of mice, which mimic the human population, to study ageing," said Auwerx.
Advertisement

The scientists started by examining mice's mitochondria -- a cell's version of a power plant -- and uncovered a group of three genes that affected the animals' life-span via their speed of functioning.

Those whose genes were 50 percent slower lived some 250 days longer, or about 30 percent of a mouse's lifetime.

"Based on this observation, we switched model, and started validating this experimentally in a worm," said Auwerx.

"Knocking down the same proteins, we could see an up to 60 percent extension of worm life-span," he added.

Auwerx underlined that since mitochondria are bacteria living within cells, his team then experimented with antibiotics, which target bacteria.

"We could see that treating the worms with the antibiotics also mimicked the genetic effects, and they also lived 60 percent longer," from 19 days to 30, he explained.

Mitochondria transform nutrients into various kinds of protein, and several previous studies have suggested that they may be the motor of ageing.

The Swiss team, working with counterparts in the Netherlands and United States, managed to identify the specific gene involved in the process and work out how variations in protein could affect life-span.

They worked out that so-called MRPs -- for mitochondrial ribosomal proteins -- had an inversely proportional impact on longevity.

In addition, they found that a lack of MRPs at key moments of an individual's early development caused stress on mitochondria.

This has short-term negative impacts such as a fall in fertility, but in the long term appeared to result in a better muscle structure as well as a longer life.

The researchers underlined that further studies would be needed to confirm whether antibiotics could be used to rein in ageing in mammals.

Source: AFP
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Cervical Cancer Awareness Month 2022
Ultra-Low-Fat Diet
Goji Berries May Protect Against Age-Related Vision Loss
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Anti-ageing and Benefits of Red Wine Ageing and Sleep Ageing 

Recommended Reading
New Factor That may Contribute to Skin Ageing
A new study reveals evidences that longwave ultraviolet radiation may induce the formation of a ......
Ageing Diminishes Ones Ability to Imagine Things: Study
Old age not only steals a person's most memorable memories, it also diminishes his ability to ......
Ageing and Sleep
Sleep is a barometer of good health in the elderly. Sleep problems in the elderly are controlled by ...
Anti-Ageing and Benefits of Red Wine
Ageing process has always been an enigma. Recent research indicates that red wine could delay the .....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)