Protein Prevents Burning of Fat and Weight Loss

Brown fat has attracted a lot of interest in recent years among obesity researchers. Body fat is essential for maintaining an appropriate energy balance and regulating body temperature. But not all fat is the same. The body contains two types of fat tissue: white adipose tissue is a store of excess calories, whereas brown adipose tissue is considered a 'good' fat that burns lipids to maintain body temperature. Brown fat can be activated by cold to "generate heat instead of storing fat," explained Sabio. But the most interesting observation is that "white adipose tissue can be converted into brown adipose tissue, thus increasing body temperature." According to Dr. Sabio, this has led to a burgeoning interest in the clinical potential of brown fat, since "activation of this tissue could reduce excess weight." According to Nuria Matesanz, the results of the study indicate that obese individuals lose the ability to activate brown fat or to convert white fat into brown, and therefore are unable to lose weight via this route.

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The researchers found that the inability to convert white fat to brown in obese patients is caused by increased amounts of the protein kinase MKK6. Through the use of animal models, the research team was able to demonstrate that MKK6 prevents the conversion white fat into brown. Mice lacking MKK6 have more brown fat; consequently, these mice are protected against obesity and eliminate excess energy as heat.

The research also demonstrated that eliminating MKK6 after mice had become obese stopped the further development of obesity and led to a drop in body weight. These findings all point to the potential of MKK6 as a therapeutic target in the fight against obesity.

The complete study is available at Nature Communications.

Source: Eurekalert