About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

A Peek into Gonorrhea Superbug’s In-Genius Defense may Help Us Destroy It

by Rishika Gupta on April 5, 2018 at 11:55 AM
Font : A-A+

 A Peek into Gonorrhea Superbug’s In-Genius Defense may Help Us Destroy It

New insights on how the gonorrhea bacteria cleverly escape the immune system have been discovered in the study. The findings of this study are published in the journal of PLOS Pathogens.

Gonorrhea which is caused by Neisseria gonorrhoeae can rapidly develop resistance to known antibiotics, and that's why this discovery is important as it could open up ways for new therapies to treat this disease.

Advertisement


Gonorrhea is caused by bacteria which can rapidly develop resistance to all known antibiotics - commonly called 'superbugs.' Gonorrhea superbugs have now been detected in every Australian state and territory and are increasingly difficult to treat in the clinic.

Every year, more than 100 million people worldwide develop the sexually transmitted disease gonorrhea, with health consequences such as infertility, transmission of the disease to newborn babies, and increased risk of HIV infections. There has been a 63 percent rise in gonorrhea in Australia over the past five years.
Advertisement

Monash University researchers have discovered a way the gonorrhea bacteria cleverly evade the immune system - opening up the way for therapies that prevent this process, allowing the body's natural defenses to kill the bug.

Dr. Thomas Naderer and Dr. Pankaj Deo and their team from the Monash Biomedicine Discovery Institute, have discovered how the gonorrhea-causing superbug (which is very small) creates even smaller packages of bacterial membrane blebs, termed vesicles, which attack immune cells.

Using cutting-edge super-resolution microscopy, which is able to see, and film, the most minute of events - the researchers found that these membrane vesicles interacted with the cells in the human immune system called 'macrophages,' triggering these to die in an orchestrated suicide process. Macrophages are the cells within the immune system that ordinarily kill foreign invaders like bacteria and viruses, so without them, the gonorrhea bacteria can flourish.

Dr. Naderer said that this new understanding of how the gonorrhea bacteria interact and cause the death of immune system cells "may lead to strategies to combat gonorrhea infection and its symptoms."

The research may also provide information as to how other bacteria evade the immune system and be unaffected by antibiotics. The 2016 Review on Antimicrobial Resistance Final Report and Recommendations states that antibiotic-resistant infection will kill an extra 10 million people a year worldwide - more than currently die from cancer - by 2050 unless action is taken.

Read the full paper in PLOS Pathogens titled 'Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis.'

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Gonorrhea Vaginitis Prostitution: Fresh Stakes in the Oldest Trade Amyotrophic Lateral Sclerosis (ALS) Acute Coronary Syndrome 

Recommended Reading
Prevalence of Drug-Resistant Gonorrhea High In China
Gonorrhoea can be treated with antibiotics but the prevalence of drug resistance to gonorrhea is ......
One Step Closer to Developing Gonorrhea Vaccine
Understanding the mechanism behind a multicomponent protein complex known as beta-barrel assembly .....
The Fight Against Antimicrobial-Resistant Gonorrhea
The recommended dual therapy of ceftriaxone-azithromycin remains effective, but treating gonorrhea ....
Gonorrhea Vaccine Key Discovery Raises Hope for Treatment
Pathogens that cause gonorrhea is highly resistant to current treatments. Discovery of a pair of ......
Acute Coronary Syndrome
Acute coronary syndrome (ACS) is a sudden, acute life-threatening condition caused by a dramatic red...
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Gonorrhea
Gonorrhea is a very common sexually transmitted disease (STD) caused by a bacterium/superbug called ...
Prostitution: Fresh Stakes in the Oldest Trade
Prostitution has broadened its base to include street prostitution, massage brothels, gigolo outcall...
Vaginitis
Vaginal infection or vaginitis occurs due to an overgrowth of bacteria or yeast or trichomoniasis ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use