About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Novel Treatment for Obesity and Fatty Liver

by Mohamed Fathima S on February 1, 2019 at 9:50 AM
Font : A-A+

Novel Treatment for Obesity and Fatty Liver

Around 27 molecules that can activate a specialized protein called PPAR-delta have been found out by a group of researchers. This protein can fight against obesity, fatty liver, diabetic nephropathy and also heals wounds.

News of these findings was published today in Scientific Reports, a Nature journal, and was made possible thanks to a new, award-winning algorithm that Goldblum's team developed. This algorithm sifted through a database of 1.56 million molecules and picked out 27 with a strong therapeutic potential, as determined by biologists at the Novartis Genomic (GNF) Institute in San Diego.

Advertisement


To date, these new molecules are undergoing pharmaceutical evaluations to treat two main health conditions. The first is Fatty Liver Disease, also known as NASH (Non-Alcoholic SteatoHeptatis). This disease currently has no cure and is a leading cause of liver cancer in the Western world. The second is obesity. PPAR-delta activation has the potential to increase physical endurance and trim waistlines by getting muscle cells to burn more fat. Future evaluations will hopefully include testing treatments for improved wound healing, and to prevent kidney toxicity in diabetics.

Professor Goldblum is cautiously optimistic about these findings. "With such a large group of highly active molecules, there is a high probability to find treatments for several common diseases. However, we should wait till all the experiments are done before we get our hopes up too high," he shared.
Advertisement

To date, there is much pharmaceutical interest in Goldblum's new molecules. Integra Holdings, Hebrew University's biotech company, determined that 21 of the 27 have the potential to reach pharmaceutical success, especially as a possible cure for Fatty Liver disease. Additionally, Israel's Heller Institute of Medical Research is currently testing PPAR-delta's physical endurance properties on mice. Goldblum predicts that in a few years we will hopefully be seeing several of these molecules in the pipeline for clinical studies on humans.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
Emotional Healing
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bariatric Surgery Obesity Hepatitis A Bulimia Nervosa Body Mass Index Liposuction Liver Wilson's Disease Battle of the Bulge Diabesity 

Recommended Reading
Fatty Liver Disease: A Growing Health Problem in India
Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and .....
Fibroscan for Fatty Liver Cirrhosis and Fibrosis
Recently, Fibroscan has incorporated the noninvasive Controlled Attenuation Parameter technique to ....
Alcoholic Liver Disease
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease....
Liver Cirrhosis
Liver cirrhosis is a chronic liver disease that arises due to alcoholism, hepatitis, or other ......
Battle of the Bulge
The ‘battle of bulge’ is the toughest of all battles. Once you put on weight it is so difficult to g...
Body Mass Index
Body mass index (BMI) is a simple tool that is generally used to estimate the total amount of body f...
Bulimia Nervosa
The term ''Bulimia'' refers to episodes of uncontrolled excessive eating, known as "binges," followe...
Diabesity
With more than one billion people affected, diabesity is the largest epidemic in the world today. Fo...
Hepatitis A
Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. H...
Liposuction
Liposuction is a cosmetic procedure, which is used to suck out the excess or abnormal fat deposition...
Obesity
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the heal...
Wilson's Disease
This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before o...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use