A team of researchers has successfully developed a treatment that has resulted effective against a specific strain of the Ebola virus.
Researchers from the University of Texas Medical Branch at Galveston and Tekmira Pharmaceuticals Corp., demonstrated that the treatment is the first to be shown effective against the new Makona outbreak strain of Ebola in animals that were infected with the virus and exhibited symptoms of the disease.
The treatment uses a sequence specific short strand of RNA, known as siRNA, designed to target and interfere with the Ebola virus, rendering it harmless. One of the advantages of this approach is the ability to quickly modify it to different viral strains.
Although all infected animals showed evidence of advanced disease, those receiving treatment had milder symptoms and recovered fully. The untreated controls succumbed to the disease on days eight and nine, which is similar to that reported in the field after patients begin showing symptoms of Ebola.
This treatment also protected against liver and kidney dysfunction and blood disorders that occur during an Ebola infection. These results indicate that the treatment may confer protective benefits that go beyond improving survival rates and effective control of virus levels in the body.
The Tekmira siRNA-based therapeutic is now being evaluated in Ebola-infected patients in Sierra Leone.
The study appears in the Nature Journal.