About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

A Molecular Subtype of Bladder Cancer Resembles Some Forms of Breast Cancer

by Dr. Trupti Shirole on March 18, 2016 at 11:59 PM
Font : A-A+

 A Molecular Subtype of Bladder Cancer Resembles Some Forms of Breast Cancer

Bladder cancer is a common urologic cancer that begins most often in the cells that line the inside of the bladder. It is the fourth most common cancer among men in the United States. While low-grade tumors have a very favorable prognosis, muscle-invasive and metastatic tumors have poorer survival rates.

In this month's issue of JCI Insight, William Kim, Benjamin Vincent, and a research team from the University of North Carolina characterized a new subtype of muscle-invasive bladder cancer that shares molecular signatures with some forms of breast cancer.

Advertisement


A subset of triple-negative breast cancers express low levels of the tight junction protein claudin. The UNC researchers now document that claudin-low tumors represent a specific subtype of bladder cancer as well.

Using data from the The Cancer Genome Atlas (TCGA) urothelial bladder carcinoma data set, they found that claudin-low tumors express high levels of immune-related genes, but also show a strong signature of immunosuppression.
Advertisement

These findings suggest that claudin-low bladder cancers may be particularly responsive to immunotherapy-based treatments that derepress the immune system.

Future studies will be needed to clinically test immune checkpoint inhibitors in this population.

Source: Eurekalert
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

A Molecular Subtype of Bladder Cancer Resembles Some Forms of Breast Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests