About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

A Key to Developing New Breast Cancer Treatments Linked to Prolactin Receptor

by Dr. Trupti Shirole on October 26, 2016 at 10:09 PM
Font : A-A+

 A Key to Developing New Breast Cancer Treatments Linked to Prolactin Receptor

Triple negative breast cancer (TNBC) refers to a tumor that is estrogen receptor-negative, progesterone receptor-negative and HER2-negative. It is the most aggressive type of breast cancer and it is very difficult to treat.

A study conducted at the Research Institute of the McGill University Health Center (RI-MUHC) suggests screening breast cancer patients for the prolactin receptor could improve the prognosis for patient and may help them avoid unnecessary and invasive treatments.

Advertisement


Using a database of 580 women with TNBC, the researchers found that survival was prolonged in patients who expressed the prolactin receptor and that prolactin hormone was able to reduce the aggressive behavior of cancerous cells. It does so by decreasing their ability to divide and form new tumors. The research was published in the journal Scientific Reports.

Dr. Ali, a researcher from the Cancer Research Program at the RI-MUHC and lead author of the study, said, "While prognosis and treatment options for breast cancer patients as a whole have improved in recent decades, this is not true for women who develop TNBC - they still have limited options for targeted treatment strategies, often require invasive chemotherapy and have a poor prognosis."
Advertisement

The reason for this is that TNBC cancers are diverse and do not behave in the same manner in all patients, something that researchers have not fully understood. However, Dr. Ali's team may have found the key to unlock this mystery. They discovered that women with tumors that express the prolactin receptor had a less aggressive breast cancer and a far better prognosis. Furthermore, in a preclinical animal model, they determined that if the prolactin receptor was not present, the tumor cells were not just more aggressive, but also proliferative and invasive compared with the ones that express the prolactin receptor.

The results suggest that screening for the prolactin receptor could indicate which patients might benefit from prolactin treatment as a single agent, or in combination with less aggressive chemotherapy," explains Dr. Ali. "We think this could be a revolutionary path to developing new treatments for breast cancer.".

Women's health and prolactin

The role of prolactin in breast cancer is not fully characterized and still controversial. Better understanding of its role in cancer could have directly impact in doctor advice to patients with high risk of developing breast cancer to practice breastfeeding as a protective measure. These findings are consistent with past studies suggesting that prolactin has a suppressing effect on breast cancer. Dr. Ali states "our research supports that breastfeeding is not only beneficial for infants but also for the mothers. Since breastfeeding is a natural way to produce prolactin in high levels, breastfeeding would actually reduce a woman's risk of developing breast cancer".

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer Tattoos A Body Art Breasts - Structures and Types 

Most Popular on Medindia

Blood - Sugar Chart Find a Hospital Find a Doctor Accident and Trauma Care Blood Donation - Recipients Blood Pressure Calculator Vent Forte (Theophylline) Diaphragmatic Hernia Noscaphene (Noscapine) Pregnancy Confirmation Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

A Key to Developing New Breast Cancer Treatments Linked to Prolactin Receptor Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests