About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

A Drug That Promises to Protect The Brain After A Stroke

by Savitha C Muppala on March 1, 2012 at 11:03 PM
Font : A-A+

 A Drug That Promises to Protect The Brain After A Stroke

Scientists have discovered an experimental drug which is capable of protecting the brain after a stroke.

This drug has been in development for a few years.

Advertisement

At this point, it has reached the most advanced stage of development among drugs created to reduce the brain's vulnerability to stroke damage (termed a "neuroprotectant").

Over 1000 attempts to develop such drugs by scientists worldwide have failed to be translated to a stage where they can be used in humans, leaving a major unmet need for stroke treatment.
Advertisement

The drug developed by the scientists at the Toronto Western Research Institute (TWRI), Krembil Neuroscience Center, is the first to achieve a neuroprotective effect in the complex brain of primates, in settings that simulate those of human strokes. ischemic stroke.

The new study shows how the drug, called a "PSD95 inhibitor" prevents brain cell death and preserves brain function when administered after a stroke has occurred.

"We are closer to having a treatment for stroke than we have ever been before," said Dr. Michael Tymianski, TWRI Senior Scientist and the study's lead author.

"Stroke is the leading cause of death and disability worldwide and we believe that we now have a way to dramatically reduce its damaging effects."

During a stroke, regions of the brain are deprived of blood and oxygen. This causes a complex sequence of chemical reactions in the brain, which can result in neurological impairment or death.

The PSD95 inhibitor published by the Toronto team acts to protect the brain by preventing the occurrence of these neurotoxic reactions.

The study used cynomolgus macaques, which bear genetic, anatomic and behaviour similarities to humans, as an ideal model to determine if this therapy would be beneficial in patients.

Animals that were treated with the PSD95 inhibitor after a stroke had greatly reduced brain damage and this translated to a preservation of neurological function.

These improvements were observed in several scenarios that simulated human strokes. Specifically, when the treatment was given either early, or even at 3 hours, after the stroke onset, the animals exhibited remarkable recoveries.

Benefits were also observed when the drug therapy was combined with conventional therapies (aimed at re-opening blocked arteries to the brain). Beneficial effects were observed even in a time window when conventional therapies on their own no longer have an effect.

"There is hope that this new drug could be used in conjunction with other treatments, such as thrombolytic agents or other means to restore blood flow to the brain, in order to further reduce the impact of stroke on patients," said Dr. Tymianski.

"These findings are extremely exciting and our next step is to confirm these results in a clinical trial," Dr. Tymianski added.

The study has been recently published in the journal Nature.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Goji Berries May Protect Against Age-Related Vision Loss
Tapping — A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Parkinsons Disease Parkinsons Disease Surgical Treatment Diet Lifestyle and Heart Disease Mitral Valve Stenosis And Mitral Valve Replacement Congenital Heart Disease Signature Drug Toxicity Stress and the Gender Divide Stroke Facts Stroke 

Recommended Reading
How to Deal with a Stroke
Stroke is a brain attack, which occurs when the blood supply to the brain is interrupted. It ......
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in .....
Aphasia
Aphasia is a condition where the patient has a language disorder. The patient has problems with ......
Diet and High Blood Pressure
High blood pressure or hypertension is defined as a blood pressure of above 140 mm Hg (systolic) ......
Congenital Heart Disease
Heart diseases that are present at birth are called “ Congenital heart diseases”....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Mitral Valve Stenosis And Mitral Valve Replacement
Mitral valve replacement is a surgical heart procedure to correct either the narrowing (stenosis) or...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Stroke
Stroke can cause permanent disability and it is important to recognize its early warning signs to st...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)