by Trilok Kapur on  April 5, 2010 at 3:06 PM Women Health News
 Using Human Foreskin, Not Lab Rats for the
Greener, cleaner cosmetics are on the march with testing of new creams on bits of human foreskin to spare lab rats, or whipping seaweed and spicy Sichuan pepper into potions.

"If you develop a product that's pleasant, efficient and safe, but that wastes energy and water, you're not doing your job," Gerard Redziniak, head of the 1,600-member French Society of Cosmetology, told AFP.

Speaking at a two-day international congress on cosmetics research in this French city, Redziniak added, however, that despite scientific advances in the field, the aim of the game broadly remained unchanged.

"The dream of finding the fountain of youth is our driving force, this desire to stay young, to look young."

Sichuan pepper for instance, a favoured spice in Chinese and Japanese cooking, blocks electric signals on skin, enabling it to reduce irritation after a hair-dye or mosquito bite, but also "giving an immediate lift", said Christian Artaria of Italian research lab Indena.

"We're working on a wrinkle reduction formula," he added.

One of the world's leading beauty firms, Guerlain, has long tabled on the orchid to freshen up tired skin, because of a hardy DNA enabling its survival in the most extreme plant world conditions.

Seaweeds, which likewise have learnt to survive harmful ultraviolet rays as well as living out of water for long periods at low tide, are ideal contenders for anti-aging, moisturizing and toning, said Greek researcher Vassilios Roussis, who reckons there are at least 25,000 known species.

"Marine algae work far better against the sun than synthetic sun screens," he said.

The good news for animals is that research increasingly is tested on bits of reconstructed human skin, made from human foreskin cells (keratinocytes) from one or several donors, grown in vitro for between a week to a month.

A pioneer in the use of reconstructed skin samples, L'Oreal based its knowhow from the 80s on techniques used to treat severe burns. It now produces 150,000 human skin samples a year.

"It's far better to work on human in vitro than on animal in vitro, which is totally distinct from human skin," said L'Oreal's tissue engineer Annie Black.

Two of the company skin types, Episkin and SkinEthic, have been rubberstamped by the European Centre for the Validation of Alternative Methods which gives the green light to non-animal tests. A US model, EpiDerm by MatTek, also has been approved by ECVAM.

Pigments and immune cells can also be introduced as well as sick cells. L'Oreal for instance has formulated a skin type including hypersensitivity to the sun.

Will scientists soon be offering reconstructed skin with hair? "We're working on it," said Black. "But it's a bit like the search for the Holy Grail."

Greening the industry by preferring nature's output over synthetics was all very well, said French chemist Chantal Larpent, but what about avoiding toxic solvants harmful to the environment.

"Water is a cheap, safe and non-toxic solvent," she said.

Source: AFP

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