Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned

by Dr. Trupti Shirole on  January 27, 2011 at 1:20 PM Drug News
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After several years of debate regarding the safety of nimesulide, cisapride and phenylpropanolamine (PPA) the Drug Controller General of India (DCGI) Dr. Surinder Singh has finally decided to ban these three unsafe drugs. Since the adverse effects of these drugs outweigh the benefits the Drugs Technical Advisory Board (DTAB) that had been examining the safety of the three drugs for several years has now recommended their withdrawal from the market.
 Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned
Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned

Nimesulide was the most controversial among the three drugs. Many developed countries like US, Britain, Canada, Sweden, Denmark, Australia, New Zealand, Japan and other 168 countries had already banned these drugs. However it is freely sold in India by prominent pharmaceutical companies like Dr Reddy's, Panacea Biotech and several others. Cisapride, another unsafe drug was found to increase upper gastrointestinal tract motility. Due to its side effects even this drug is banned in many countries. The drug continued to remain in the market even though the possible dangerous side effects of the drug had been brought to the notice of the DCGI 10years back. PPA used in cold and cough remedies is freely available in India. However it was banned in North America and Western Europe some years ago. The DTAB is now reviewing the use of Gatifloxacin, tegaserod and deanxit which have been banned in some of the developed countries. In the past diabetes drug Rosiglitazone and anti-obesity drug Rimonabant have been banned from the Indian markets.

This shows the need for stricter evaluation of safety and efficacy of any new drug before introducing it in the market.

Source: Medindia

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It is a tragedy that nimuselide has become a victim of marketing strategy and has been banned. This drug is safer and more effective then paracetamol. The judges and counselors involvement in the ban have been a weapon to bring about a ban to an effective drug that has been utilized for years with out much side effect. In certain context it has been safer then paracetamol. In the pediatric group it has been safer then paracetamol in many clinical conditions. The judges and lawyers involved have not done there job to bring about this ban, They definitely had the wrong inputs. It has been one of the best inventions to mankind in the last thirty years which have been guillotined by vested pharmaceutical companies. In fact the pharmaceutical companies that have brought about this ban should be criminally prosecuted.

I'm using NISE[nimesulide from DRL] from 6years and I never had any side effect because of that. And it works awesome for acute pain. I don't know why people get carried away! Nothing in this world have 100% advantages and no disadvantages. In my personal opinion, nimesulide works better than paracetamol for acute pain

Idiots wasn't need to be banned nimesulide,ppa and sibutramine bcoz in india they didn't caused fatal cases,in real they were safe.ppa & sibutramine is known for it's beneficial use in anti-decongestant(only ppa),obesity,fatigue,energy,sexual arousal,sleepiness,drowsiness, as respiratory stimulants,in urinary incontinence,anhedonia and in priaprism.look it has alot benefits. NOW WE DON'T HAVE ANY MEDICINE FOR ABOVE PURPOSE UNFORTUNATELY. Indian govt.should unbanned these medicines.people pls fight for it.


Sir, Despite ban Phenypropanoleamine [PPA] is still continued to be on sale. infact many of the companies have replaced the safer pseudoephedrine salt with PPA despite the reports of poor safety profile. Only strict action against these companies will help to safegaurd the patients, like cancellation of their licences and imposing heavy fines worth crores.

Sir, So many drugs have already banned but it is not effected legally.Why? No chemist has been arrested till now.If any chemist has been arrested for saling ie,nimesulide,phenylpropanolamin etc.,it will be the legal record in India. Comment from A.Debendro Singh,Manipur.


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