Study Profiles Patients at Increased Risk of Sudden Death in Chronic Epilepsy

by Tanya Thomas on  December 9, 2010 at 10:48 AM Mental Health News
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Sudden unexpected death in epilepsy (SUDEP) is the most common condition-related cause of death in chronic epilepsy. Case-control studies using living people with epilepsy as controls have aimed at identifying factors that distinguish the epilepsy patient at risk of SUDEP, but there are disagreements between studies and a lack of precision in the risk estimates attributed, in part, to the small number of cases in each study. To counterbalance these study limitations, the Epidemiology Task Force of the International League Against Epilepsy (ILAE) pooled data from four published studies of SUDEP from the U.S., Sweden, Scotland and England.
 Study Profiles Patients at Increased Risk of Sudden Death in Chronic Epilepsy
Study Profiles Patients at Increased Risk of Sudden Death in Chronic Epilepsy

SUDEP in the study was defined as 1) having a history of epilepsy (one or more seizures during a five-year period), 2) death occurring suddenly, 3) death unexpected with no life-threatening illness, 4) death remaining unexplained after all investigative efforts, including autopsy. (Platform C.03)

Analysis of the pooled data revealed statistically significant risk factors for SUDEP, including increased frequency of generalized tonic-clonic seizures (GTCS), taking more than one anticonvulsant medication (AED), long duration of epilepsy, young age at onset, gender, symptomatic cause, and lamotrigine therapy. The results persisted for both people younger than age 16 and for adults over the age of 16.

According to epidemiologist Dale C. Hesdorffer, Ph.D., of Columbia University, "The emerging profile from our pooled analysis indicates that people with early onset refractory symptomatic epilepsy who have frequent GTCS and take more than one AED are at highest risk. The results suggest that reducing the number of these generalized seizures is a priority of more importance than reducing the number of AEDs."

The researchers also say the role of AEDs and other forms of treatment should be analyzed further in future studies. A further challenge for future research is to focus on patients with refractory epilepsy to clarify what features may distinguish the patients in this high risk population that die in SUDEP from those who survive.

Editors Note: Authors of this study will be available for a press briefing on Monday, December 6, at 3:00 PM in the onsite press room, Room 101B, of the Henry B. Gonzales Convention Center. To join by phone dial in on 1-866-740-1260; PIN 5867508#

About the American Epilepsy Society (AES)
The American Epilepsy Society, based in West Hartford, CT, seeks to advance and improve the treatment of epilepsy through the promotion of epilepsy research and education for healthcare professionals. Society membership includes physicians and scientists concerned with the study and treatment of epilepsy (epileptologists) and allied professionals who care for people with seizure disorders.

Source: Newswise

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WHO will study and research the facts that MonoSodiumGlutamate aka MSG, CARRAGEENAN aka MSG, Soy Protein Isolates/Concemtrates aka MSG YEAST EXTRACT aka MSG and Nitrates found in hams/pork products and all smoked seasoned foods, all those things Can and do cause GRAND NAL seizures and can cause them quicker if a person has any scar tissue or leisons on the brain. Hello I am living with the facts above with a leison and now without a leison for ten years. Someone needs to take people like me serious before we all may die from SUDEP thanks to the foods and drinks we consume. Some people like myself knows from our brain reactions if a food or drink is safe to eat when a product claims NO MSG yet it has MSG in it called by another name. It's been 50 years now that I have lived with the condition of seizures. I would think there would be one person out there somewhere who would believe everything I have said about my condition. I thought N I H would had been that place but I was wrong. They are not right on everything NINDS claims is the causes of seizures / epilepsy. No one there I knew lived with it to know what it is like to live with a condition you hate. Life is great knowing that others do not know everything. If I knew everything, I never would ever have any more Grand Mal seizures or auras.


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