Moderate calorie restriction causes temporal changes in the liver and skeletal muscle metabolism, while moderate weight loss affects muscle, reveals study on obese patients.
Led by Dr. Samuel Klein of the Washington University School of Medicine, the study has also revealed that short-term calorie restriction (CR) with a low-carbohydrate diet caused a greater change in liver fat content and metabolic function than short-term CR with a high-carbohydrate diet.
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While the consumption of energy-deficit diets is considered to be very significant for obesity treatment, the most appropriate macronutrient composition of diet therapy needed to improve metabolic health remains controversial.
"Our data underscore the complexity of the metabolic effects of calorie restricition with diets that differ in macronutrient composition, and demonstrate differences among organ systems in the response to calorie restriction and subsequent weight loss," said Dr. Klein.
Educated Choose Low Calorie and Nutritious Diets, but Pay More
St. Louis, MO, May 1, 2009 – As people become more educated, studies have demonstrated that they tend to choose foods that are lower in calories but higher in nutrients. They also
St. Louis, MO, May 1, 2009 – As people become more educated, studies have demonstrated that they tend to choose foods that are lower in calories but higher in nutrients. They also
During the study, his team randomised 22 obese patients to a high-carbohydrate or low-carbohydrate energy-deficit diet.
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Liquid Calories More to be Blamed for Weight Gain
Want to shed those extra pounds? Well, then focus more on what you drink than what you eat, a new study suggests.
Want to shed those extra pounds? Well, then focus more on what you drink than what you eat, a new study suggests.
Dr. Klein says that his team's efforts showed that short-term CR caused a rapid decrease in IHTG content, an increase in hepatic insulin sensitivity and a decrease in endogenous glucose production rate, while longer-term CR and a moderate 7 percent weight loss improved skeletal muscle insulin sensitivity in conjunction with an increase in cellular insulin signalling.
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A research article on the study has been published in the journal Gastroenterology.
Source-ANI
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