The full details about the molecules and mechanisms that underlie the development of autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, remain to be discovered. One compound that may have a role in alleviating these conditions is quinoline-3-carboxamide, which is currently being tested in various clinical trials.
In this week's PLoS Biology, researchers from Lund University, Sweden, the University of Munster in Germany, and the company Active Biotech AB, identify a molecular target for quinoline compounds.
Multiple sclerosis - Symptoms - Causes - Diagnosis - Treatment
Multiple sclerosis can be a severely disabling autoimmune disease that affects the myelin or insulating layer of the nerve fibers and typically has remissions and relapses
Multiple sclerosis can be a severely disabling autoimmune disease that affects the myelin or insulating layer of the nerve fibers and typically has remissions and relapses
The published data describe a new mechanism whereby S100A9 can promote pro-inflammation at early stages of immune activation. These findings may lead to an increased understanding of the early steps in the development of autoimmune disease.
Three of Active Biotech's projects (laquinimod, 57-57 and TASQ) belong to the quinoline chemical class of compounds.
Source-Eurekalert
LIN
UK Watchdog Calls for Food Additives Ban Over Child Hyperactivity Fears
Europe's main consumer watchdog called Thursday for an EU-wide ban on six food colourings which a scientific study has linked to hyperactivity in children.
Europe's main consumer watchdog called Thursday for an EU-wide ban on six food colourings which a scientific study has linked to hyperactivity in children.
Peptide, DNA Duo may Help to Combat Autoimmune Disease
A new research has revealed that a human peptide called LL37, when coupled with body’s own DNA, works as a natural antibiotic against invading microbes.
A new research has revealed that a human peptide called LL37, when coupled with body’s own DNA, works as a natural antibiotic against invading microbes.
