Researchers Find H1N1 Flu Vaccine Safe in Patients With Kidney Failure or Transplant

by Kathy Jones on  August 21, 2011 at 7:26 PM Research News
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It is well-known that when the influenza A (H1N1) virus swept around the world in spring 2009, infection was presumed to be more common in immunosuppressed patients, such as those who have had a kidney transplant.
 Researchers Find H1N1 Flu Vaccine Safe in Patients With Kidney Failure or Transplant
Researchers Find H1N1 Flu Vaccine Safe in Patients With Kidney Failure or Transplant

Later that year, the International Societies of Transplantation recommended that transplant recipients receive at least one dose of the H1N1 vaccine, although there was no information on the efficacy of the vaccine in that population.

Marta Crespo, MD, and Julio Pascual, MD, PhD (Parc de Salut Mer, Barcelona, Spain), have now evaluated the efficacy of the H1N1 vaccine in patients who had received a kidney transplant, as well as those on hemodialysis. They found the vaccine was safe in kidney patients, but using a single dose of the vaccine produced a poor response in patients, according to a study recently published in the Clinical Journal of American Society of Nephrology.

Included in the study were 79 kidney transplant patients, 48 hemodialysis patients, and 15 healthcare workers who had normal kidney function. All who were vaccinated received one dose of the vaccine; blood samples were tested for antibodies against the virus before vaccination and 8 weeks after.

Of the 96 people (including controls) who received the vaccine, 43.7% (42/96) developed antibodies (seroconverted). That included 41.8% of those in the kidney transplant group, 33.3% of those on hemodialysis, and 81.8% of the healthy controls. The healthy control group had a significantly better response than the other two groups; there was no significant difference in response between the other two groups. Overall, younger people were more likely to seroconvert. In the transplant group, patients who had more time since transplantation were more likely to seroconvert than those with recent transplants, and in the hemodialysis group, younger patients were more likely to seroconvert. No severe adverse effects were seen.

Although the study protocol was similar to that advised by the transplantation society, "administration of a single dose of adjuvanted vaccine produced a poor response" in transplant and dialysis patients, compared to the healthy controls, noted the study authors. "In our experience, recently transplanted patients and older patients on hemodialysis are two special populations that probably need at least two doses of vaccine to seroconvert."

"Renal patients do not show the same responses to medical problems as the general population," said Dr. Crespo. "Specific studies must be performed to evaluate the efficacy and safety of measure such as vaccination against the influenza A H1N1."

Study co-authors include Silvia Collado, Marisa Mir, Higini Cao, Francesc Barbosa, Consol Serra, Carlota Hidalgo, Anna Faura, Milagros Montero, Juan GarcĂ­a de Lomas, Juan Horcajada, and Josep M. Puig.

Disclosures: The authors of this manuscript have conflicts of interest to disclose as described by the Journal of the American Society of Nephrology. The study was performed, in part, with funding from the project ISCIII PII0/01370.

The article, entitled "Efficacy of Influenza A H1N1/09 Vaccine in Hemodialysis and Kidney Transplant Patients," will appear online at

The content of this article does not reflect the views or opinions of the American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with more than 12,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.

Source: Newswise

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