Personalized Breast Cancer Treatment may be Possible from Simple Genetic Test

by Rajshri on  May 8, 2010 at 8:22 PM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

A simple genetic test that uses just three genes is among the most effective means of classifying breast cancer into sub-types, US researchers have said.

The findings are a significant step in bringing more personalized treatment into breast cancer, say researchers.
 Personalized Breast  Cancer Treatment may be Possible from Simple Genetic Test
Personalized Breast Cancer Treatment may be Possible from Simple Genetic Test

The study is based on the already well-established fact that breast cancer is not one biologically homogeneous disease, but it is composed of several molecular sub-types each of which is characterized by distinct gene expression profiles.

"It is these differences that explain, at least in part, why patients who have tumours that appear to be similar may experience completely different clinical outcomes such as rognosis and response to anticancer therapies," said Benjamin Haibe-Kains from Dana-Farber Cancer Institute in Boston, USA.

"Thus, there is an urgent need for developing a robust tool to provide clinicians with guidance for classifying breast cancer molecular sub-types, which could then aid in making therapeutic decisions," Haibe-Kains added.

Several research groups have already developed a range of different genetic 'fingerprints' they use to assign breast cancers into different sub-types, but questions have been raised about the reliability of these groupings.

To shed new light on this issue, Haibe-Kains and colleagues performed the largest comparative study to date of breast cancer sub-types, analyzing 32 publicly available gene expression datasets including more than 4600 breast cancer patients and six different classification models.

"We studied these models in terms of concordance and prognostic value and, for the first time, we estimated their robustness: that is, their capacity to assign the same tumours to the same molecular sub-types whatever the gene expression data used to fit this model," Haibe-Kains said.

Two main classes of classification models have been published during the last decade: the Single Sample Predictor (SSP) and the Sub-type Classification Model (SCM). Over the years the list of genes used by these models have been refined, leading to the publication of six distinct classification models.

"Generally speaking, we found that SCMs yielded stronger concordance than SSPs. We also observed that SCMs, including a simple model that uses only three genes-ESR1, ERBB2 and AURKA-were significantly more robust than SSPs," Haibe-Kains said.

By demonstrating the robustness of the SCM models, the new study is a significant step towards bringing these classification models into the clinic, Haibe-Kains said.

"The robustness of SCMs makes them promising candidates for an implementation into the clinic especially in the simplest form- that is, a model using only three genes," Haibe-Kains added.

The findings were presented at the IMPAKT Breast Cancer Conference in Brussels, Belgium.

Source: ANI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Mastitis Cancer and Homeopathy Genetics and Stem Cells Cancer Facts Cancer Tattoos A Body Art Breasts - Structures and Types Varicocele Breast Lumps Breast Lumps-Screening 

News A - Z


News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive