Fighting infection, even cancer, may become quite easy for the human body if everything goes the way researchers at the Wistar Institute expect it to go. They have developed a potential therapeutic target that enables the body’s immunity- keeper, the T cells, in great shape for fighting infection.
The research team has identified seven different receptors on T cells that can suppress immune responses during a long battle with an infectious pathogen or against developing cancer.
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The key finding is that these new receptors likely control different aspects of T cell responses, such as division or expansion, controlling viral replication, and local killing of infected cells versus secretion of long-range active antiviral proteins.
"This amount of control over T cells' response is remarkable. It suggests that layers of negative regulation exist on exhausted T cells from co-expression of multiple inhibitory receptors," Nature quoted him as saying.
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"We are starting to see a picture emerging of a really tuneable array of inhibitory receptors expressed on T cells.
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"This presents us with a great clinical opportunity. T cells have a lot of weapons at their disposal to control viral infection and most of them are disarmed when these cells become exhausted.
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The study appears in journal Nature Immunology.
Source-ANI
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