Neuropathic Pain Drug also Provides Relief from Abdominal Adhesions

by Rajshri on  October 28, 2009 at 8:20 PM Drug News
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A Henry Ford study has revealed that a drug approved for neuropathic pain, effectively reduced abdominal pain and improved sleep in women with adhesions.
 Neuropathic Pain Drug also Provides Relief from Abdominal Adhesions
Neuropathic Pain Drug also Provides Relief from Abdominal Adhesions

Adhesion pain, a common complication after abdominal or pelvic surgery, currently lacks effective therapy. Adhesions can also form after infections in the bowel such as diverticulitis.

"Many patients in the study went from debilitating pain to complete resolution of pain on pregabalin," says Ann Silverman, M.D., senior staff gastroenterologist at Henry Ford Hospital and lead author of the study.

Study results will be presented Oct. 26 at the American College of Gastroenterology's Annual Scientific Meeting in San Diego.

"Aside from the use of analgesics, additional surgery is the only treatment option for abdominal pain from adhesions but repeat surgery can lead to more adhesions," says Dr. Silverman.

The estimates of abdominal adhesion formation following surgery have been found to be as high as 100 percent in certain studies. Surgery is only recommended for bowel obstruction.

The randomized Henry Ford study looked at 18 women who received the drug or a look-alike placebo. All patients had previous abdominal surgery and were similar in age. The first eight weeks was a randomized placebo controlled trial of pregabalin followed by a four-week open label study in which all patients received the active study drug.

The primary objective was to demonstrate a significant reduction in pain scores.

The pain score result from the blinded phase indicated that the amount of decrease was significantly greater in the drug group (p-value = 0.024) compared with those on placebo, while the pain score resulted from the open label setting indicated that the amount of decrease was significantly greater in the placebo group (p-value = 0.043). This would be expected since those on active drug continued to take active drug and patients who had received the look-alike placebo received the active drug only during this phase of the study.

Source: Eurekalert

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Could you update me on the Henry Ford study done on abdominal adhesions and the effective treatment done with pregabalin. My wife has abdominal adhesions with the classic symptoms of nausea, extreme pain and etc due to numerous surgeries done over 20 years ago, but the symptoms are just now revealing themselves. Over the past 4 months the episodes are becoming more frequent. Her family dr has referred her to a local gastroenterologist and we are waitng on the initial appt date. I am going to show him this article, but I suppose pregabalin has not been approved yet for treatment of abdominal adhesions, is that correct? Any information will be appreciated. Thank you.

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